(Q41331100)

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Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65.

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Europe PubMed Central

PMC publication ID

29 September 2017

Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65. (English)

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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author name string

Hideaki Shimada

1

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Lakshman E Rajagopalan

2

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Europe PubMed Central

PMC publication ID

29 September 2017

language of work or name

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publication date

17 February 2010

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Europe PubMed Central

PMC publication ID

29 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

29 September 2017

285

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Europe PubMed Central

PMC publication ID

29 September 2017

17

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

12536-12542

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma

1 reference

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ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells

1 reference

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1 October 2017

Lysophosphatidic acid (LPA) and its receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

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Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling

1 reference

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Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

1 reference

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1 October 2017

Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells

1 reference

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1 October 2017

Quantitative high-throughput cell-based assays for inhibitors of ROCK kinases

1 reference

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Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis.

1 reference

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Rho kinases in cardiovascular physiology and pathophysiology

1 reference

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1 October 2017

Rho kinase, a promising drug target for neurological disorders

1 reference

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Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

1 reference

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Active participation of endothelial cells in inflammation

1 reference

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RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65.

1 reference

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1 October 2017

Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

Actin dynamics control SRF activity by regulation of its coactivator MAL

1 reference

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1 October 2017

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.

1 reference

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The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

1 reference

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1 October 2017

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

1 October 2017

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

1 reference

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1 October 2017

A nuclear factor-kappaB inhibitor BAY 11-7082 suppresses endothelin-1 production in cultured vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

11 June 2018

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

11 June 2018

TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

19 August 2018

Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

19 August 2018

Lysophosphatidic acid-LPA1 receptor-Rho-Rho kinase-induced up-regulation of Nav1.7 sodium channel mRNA and protein in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion

1 reference

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19 August 2018

Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?

1 reference

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19 August 2018

Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3282996

19 August 2018

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

1 reference

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Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells

1 reference

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19 August 2018

Lysophosphatidic acid enhances in vivo infiltration and activation of guinea pig eosinophils and neutrophils via a Rho/Rho-associated protein kinase-mediated pathway

1 reference

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19 August 2018

Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells

1 reference

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Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility

1 reference

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Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20164172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20164172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20164172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20164172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.099630

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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