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Wikidata

(Q412587)

English

CD4 molecule

mammalian protein found in Homo sapiens

  • CD4 Antigens
  • T-cell surface antigen T4/Leu-3
  • CD4 receptor
  • CD4 antigen (p55)
  • T-cell surface glycoprotein CD4
  • CD4
  • CD4 protein
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
15 references
retrieved
8 April 2019
stated in
The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Energetics of the HIV gp120-CD4 binding reaction
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cloning of ACP33 as a novel intracellular ligand of CD4
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dimeric association and segmental variability in the structure of human CD4
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural definition of a conserved neutralization epitope on HIV-1 gp120
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
MHC class II protein binding
determination method or standard
IBA
IDA
IPI
NAS
5 references
retrieved
8 April 2019
stated in
Role of CD4 and CD8 in T cell activation and differentiation
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
NAS
retrieved
8 April 2019
stated in
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction between CD4 and class II MHC molecules mediates cell adhesion
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IDA
retrieved
8 April 2019
stated in
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IBA
cell component
plasma membrane
determination method or standard
IDA
TAS
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IEA
retrieved
8 April 2019
stated in
The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IDA
retrieved
8 April 2019
stated in
Interaction between CD4 and class II MHC molecules mediates cell adhesion
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IDA
retrieved
8 April 2019
stated in
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
GOA
curator
UniProt
UniProt protein ID
P01730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IDA
retrieved
8 April 2019
stated in
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01730
determination method or standard
IDA
biological process
Gene Atlas image
PBB GE CD4 203547 at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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