(Q41182918)

27 September 2017

title

Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines (English)

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27 September 2017

M P Scheid

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27 September 2017

V Duronio

series ordinal

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27 September 2017

language of work or name

English

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publication date

1 July 1996

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Journal of Biological Chemistry

27 September 2017

published in

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27 September 2017

volume

271

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27 September 2017

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27 September 2017

page(s)

18134-18139

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

27 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Wortmannin inhibits insulin-induced Ras and mitogen-activated protein kinase activation related to adipocyte differentiation in 3T3-L1 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.30.18134

21 January 2018

Identifiers

DOI

10.1074/JBC.271.30.18134

1 reference

27 September 2017

1 reference