(Q41085706)

English

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

scientific article published on October 1997

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

author name string

A Vogt

1

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

J Sun

2

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Y Qian

3

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

A D Hamilton

4

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

S M Sebti

5

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

language of work or name

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publication date

1 October 1997

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

26 September 2017

272

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

43

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

27224-27229

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

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21 January 2018

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

1 reference

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21 January 2018

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1 reference

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21 January 2018

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

1 reference

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21 January 2018

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

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21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

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21 January 2018

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

1 reference

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21 January 2018

Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells

1 reference

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21 January 2018

A Restriction Point for Control of Normal Animal Cell Proliferation

1 reference

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G1 phase progression: cycling on cue

1 reference

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Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

p21 is a universal inhibitor of cyclin kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

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21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

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21 January 2018

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

1 reference

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21 January 2018

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

1 reference

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21 January 2018

A cell cycle-regulated inhibitor of cyclin-dependent kinases

1 reference

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21 January 2018

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1 reference

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21 January 2018

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

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21 January 2018

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

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21 January 2018

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

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21 January 2018

Human cell line (COLO 357) of metastatic pancreatic adenocarcinoma

1 reference

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21 January 2018

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

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21 January 2018

A Detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis

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21 January 2018

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

1 reference

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21 January 2018

A role for Rho in Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.43.27224

21 January 2018

Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription

1 reference

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21 January 2018

Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity

1 reference

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21 January 2018

Identifiers

10.1074/JBC.272.43.27224

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 September 2017

ResearchGate publication ID

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