(Q40965861)

English

A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

scientific article published on April 1999

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 September 2017

A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

author name string

R B DeMattos

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

F E Thorngate

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

D L Williams

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

language of work or name

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publication date

1 April 1999

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

19

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

2464-2473

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic expression of genes regulating lipid metabolism in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How proteins enter the nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E synthesis in peripheral tissues of nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of apolipoprotein E during nerve degeneration and regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-specific binding of apolipoprotein E to beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of rat E and chicken A-I apolipoproteins and mRNAs during optic nerve degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of protein context on nuclear location signal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E synthesis in human kidney, adrenal gland, and liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear targeting sequences--a consensus?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth of a rat neuroblastoma cell line in serum-free supplemented medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: structure-function relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risky apolipoprotein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of apolipoprotein E mRNA in rat microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein uptake by neuronal growth cones in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10087061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.19-07-02464.1999

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6786055&resulttype=core&format=json

12 May 2020

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