(Q40919280)

24 September 2017

title

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling (English)

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24 September 2017

L O Beitz

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24 September 2017

D A Fruman

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24 September 2017

T Kurosaki

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24 September 2017

L C Cantley

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24 September 2017

A M Scharenberg

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24 September 2017

language of work or name

English

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publication date

1 November 1999

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

274

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24 September 2017

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24 September 2017

page(s)

32662-32666

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PI3K: downstream AKTion blocks apoptosis

24 September 2017

cites work

1 reference

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

21 January 2018

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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

21 January 2018

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Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

21 January 2018

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SHIP modulates immune receptor responses by regulating membrane association of Btk.

21 January 2018

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21 January 2018

Phosphoinositide kinases

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Phosphoinositide 3-kinases: A conserved family of signal transducers

21 January 2018

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A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors

21 January 2018

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Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol

21 January 2018

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A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

21 January 2018

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Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain

21 January 2018

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Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

21 January 2018

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A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate

21 January 2018

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Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

21 January 2018

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Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells

21 January 2018

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Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase

21 January 2018

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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

21 January 2018

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Phosphoinositide 3-kinases and membrane traffic

21 January 2018

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Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

21 January 2018

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Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

21 January 2018

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Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling

21 January 2018

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

21 January 2018

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21 January 2018

Phosphoinositide kinases

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

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Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

21 January 2018

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

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Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells

21 January 2018

1 reference

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

1 reference

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The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

21 January 2018

1 reference

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BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

21 January 2018

1 reference

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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

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CD19 Is a Substrate of the Antigen Receptor-Associated Protein Tyrosine Kinase in Human B Cells

21 January 2018

1 reference

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Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Specific binding of Fyn and phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.46.32662

21 January 2018

Identifiers

DOI

10.1074/JBC.274.46.32662

1 reference

24 September 2017

1 reference