(Q40808903)

23 September 2017

title

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage (English)

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23 September 2017

author

Cristine Alves da Costa

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23 September 2017

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23 September 2017

Petit A

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23 September 2017

Bihel F

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23 September 2017

Pourquié O

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23 September 2017

Kraus JL

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23 September 2017

publication date

1 May 2001

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23 September 2017

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23 September 2017

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23 September 2017

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23 September 2017

page(s)

507-511

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Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

23 September 2017

cites work

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

7 January 2021

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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7 January 2021

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Presenilins: structural aspects and posttranslational events.

1 reference

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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7 January 2021

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

1 reference

7 January 2021

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

1 reference

7 January 2021

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

1 reference

7 January 2021

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

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7 January 2021

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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7 January 2021

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

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7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

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7 January 2021

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

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7 January 2021

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

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7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

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7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

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7 January 2021

Identifiers

DOI

10.1038/35074581

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23 September 2017

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