(Q40792300)

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Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

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Europe PubMed Central

PubMed publication ID

23 September 2017

Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets (English)

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Europe PubMed Central

PubMed publication ID

23 September 2017

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microglial inhibitor

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1 reference

based on heuristic

inferred from title

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based on heuristic

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Linda J Van Eldik

6

object named as

L J Van Eldik

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Europe PubMed Central

PubMed publication ID

23 September 2017

author name string

S Mirzoeva

1

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Europe PubMed Central

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23 September 2017

T Koppal

2

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Europe PubMed Central

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23 September 2017

T V Petrova

3

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Europe PubMed Central

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23 September 2017

T J Lukas

4

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Europe PubMed Central

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23 September 2017

D M Watterson

5

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23 September 2017

publication date

1 October 1999

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Europe PubMed Central

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23 September 2017

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Europe PubMed Central

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23 September 2017

844

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Europe PubMed Central

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23 September 2017

1-2

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Europe PubMed Central

PubMed publication ID

23 September 2017

126-134

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Europe PubMed Central

PubMed publication ID

23 September 2017

Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

1 reference

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7 January 2021

Bacterial endotoxin induces [Ca2+]i transients and changes the organization of actin in microglia

1 reference

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7 January 2021

Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

1 reference

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7 January 2021

Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus

1 reference

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An immortalized cell line expresses properties of activated microglial cells

1 reference

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7 January 2021

Protein kinase C eta mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes

1 reference

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7 January 2021

Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.

1 reference

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7 January 2021

Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis

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7 January 2021

Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors.

1 reference

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7 January 2021

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo

1 reference

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7 January 2021

Microglia as mediators of inflammatory and degenerative diseases

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7 January 2021

Staurosporine and K-252 compounds protect hippocampal neurons against amyloid beta-peptide toxicity and oxidative injury

1 reference

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7 January 2021

Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926

1 reference

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7 January 2021

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

1 reference

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7 January 2021

Differential regulation of cytokine-induced major histocompatibility complex class II expression and nitric oxide release in rat microglia and astrocytes by effectors of tyrosine kinase, protein kinase C, and cAMP

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

1 reference

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7 January 2021

Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Suppression of nitric oxide formation by tyrosine kinase inhibitors in murine N9 microglia

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide

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7 January 2021

Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells

1 reference

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7 January 2021

Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Nitric oxide synthase type II mRNA stability is translation- and transcription-dependent.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2

1 reference

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7 January 2021

CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Endotoxin signal transduction in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2901911-3

7 January 2021

Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene

1 reference

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7 January 2021

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements

1 reference

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7 January 2021

A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase

1 reference

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7 January 2021

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide

1 reference

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7 January 2021

Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease

1 reference

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Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity

1 reference

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7 January 2021

based on heuristic

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10.1016/S0006-8993(99)01911-3

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Europe PubMed Central

PubMed publication ID

23 September 2017

release_4shlrpgutvhl5f2f4sdy7uim2y

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https://api.fatcat.wiki/v0/release/4shlrpgutvhl5f2f4sdy7uim2y

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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