(Q40780192)

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Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation

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Europe PubMed Central

PubMed publication ID

23 September 2017

Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

author name string

Gryz EA

1

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Europe PubMed Central

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23 September 2017

Meakin SO

2

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Europe PubMed Central

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23 September 2017

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publication date

1 January 2000

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Europe PubMed Central

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23 September 2017

1 reference

Europe PubMed Central

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23 September 2017

19

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Europe PubMed Central

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23 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

417-430

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

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Transcriptional activation by tetracyclines in mammalian cells

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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Dimerization of cell surface receptors in signal transduction

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The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Signal transduction by the neurotrophin receptors

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

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Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors

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Molecular and biochemical characterization of the human trk proto-oncogene

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Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo

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Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction

1 reference

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Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex

1 reference

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The nerve growth factor family of receptors

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The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells

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Identification and characterization of novel substrates of Trk receptors in developing neurons

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SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells

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Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Growth factor signaling by receptor tyrosine kinases

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Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis

1 reference

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Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

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Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

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A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation

1 reference

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The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells

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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

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Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The neurotrophins and their receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transient association of the phosphotyrosine phosphatase SHP-2 with TrkA is induced by nerve growth factor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Deletions in the extracellular domain of rat trkA lead to an altered differentiative phenotype in neurotrophin responsive cells

1 reference

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based on heuristic

inferred from DOI database lookup

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A kinase insert isoform of rat TrkA supports nerve growth factor-dependent cell survival but not neurite outgrowth

1 reference

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inferred from DOI database lookup

Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors

1 reference

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based on heuristic

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Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1 reference

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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

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Identifiers

10.1038/SJ.ONC.1203330

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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