(Q40722405)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis (English)

1 reference

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19 February 2020

0 references

1 reference

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19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

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19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

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19 February 2020

Ben J Gu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Judith Field

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Amber Ou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Trevor J Kilpatrick

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jeannette Lechner-Scott

1 reference

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19 February 2020

Rodney Scott

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Bruce V Taylor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Melissa Gresle

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Steven Petrou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Sabine Hoffjan

1 reference

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19 February 2020

Denis A Akkad

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Colin A Graham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Stanley Hawkins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Anna Glaser

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Sahl Khalid Bedri

1 reference

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19 February 2020

Jan Hillert

1 reference

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19 February 2020

Alfredo Antiguedad

1 reference

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19 February 2020

ANZgene Consortium

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

James S Wiley

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

publication date

17 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

published in

Human Molecular Genetics

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19 February 2020

volume

1 reference

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19 February 2020

issue

1 reference

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19 February 2020

page(s)

5644-5654

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26188005%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Inflammatory cortical demyelination in early multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

A potential role for P2X7R in allergic airway inflammation in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

P2X7 receptor activation induces inflammatory responses in salivary gland epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Liaisons dangereuses: P2X(7) and the inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

P2X7 receptor polymorphism impairs extracellular adenosine 5'-triphosphate-induced interleukin-18 release from human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

The ATP4− Receptor-Operated Channel (P2Z Class) of Human Lymphocytes Allows Ba2+ and Ethidium+ Uptake: Inhibition of Fluxes by Suramin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

P2X7 receptors regulate engulfing activity of non-stimulated resting astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

The human P2X7 receptor and its role in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Point mutations confer loss of ATP-induced human P2X(7) receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Molecular physiology of P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

The effect of anions on the human P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Gain-of-function of P2X7 receptor gene variants in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

New diagnostic criteria for multiple sclerosis: guidelines for research protocols

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

PLINK: a tool set for whole-genome association and population-based linkage analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

SWISS-MODEL: An automated protein homology-modeling server

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278

P2X7 Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV278