(Q40716277)

23 September 2017

title

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? (English)

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23 September 2017

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Fuxing Tang

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23 September 2017

Kazutoshi Horie

series ordinal

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23 September 2017

Ronald T Borchardt

series ordinal

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23 September 2017

publication date

1 June 2002

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23 September 2017

published in

Pharmaceutical Research

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23 September 2017

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23 September 2017

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23 September 2017

page(s)

765-772

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describes a project that uses

23 September 2017

MDCK-MDR1

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cites work

Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane

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12 December 2020

The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface

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12 December 2020

Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers

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12 December 2020

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

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12 December 2020

Multidrug-resistance phenotype in Chinese hamster ovary cells

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12 December 2020

Dose-dependent pharmacokinetics of cyclosporin A in rats: events in tissues.

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12 December 2020

P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

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12 December 2020

The application of cell culture systems in drug discovery and development

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12 December 2020

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

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12 December 2020

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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12 December 2020

P-Glycoprotein in cell cultures: a combined approach to study expression, localisation, and functionality in the confocal microscope.

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12 December 2020

Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

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12 December 2020

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

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12 December 2020

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

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12 December 2020

Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B.

1 reference

12 December 2020

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

1 reference

12 December 2020

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

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12 December 2020

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

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12 December 2020

Multidrug resistance and the role of P-glycoprotein knockout mice

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12 December 2020

Transport of digoxin into brain microvessels and choroid plexuses isolated from guinea pig.

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12 December 2020

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers

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12 December 2020

Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene

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12 December 2020

Association of intestinal peptide transport with a protein related to the cadherin superfamily

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12 December 2020

Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.

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12 December 2020

Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.

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12 December 2020

The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier

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12 December 2020

Sorting of newly synthesized galactosphingolipids to the two surface domains of epithelial cells

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12 December 2020

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies

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12 December 2020

Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum

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12 December 2020

Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.

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12 December 2020

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

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12 December 2020

Interaction of P-glycoprotein with defined phospholipid bilayers: a differential scanning calorimetric study

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12 December 2020

Active secretion and enterocytic drug metabolism barriers to drug absorption

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12 December 2020

Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane

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12 December 2020

Epithelial sphingolipid sorting allows for extensive variation of the fatty acyl chain and the sphingosine backbone.

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12 December 2020

Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group

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12 December 2020

The multidrug resistance protein family.

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12 December 2020

P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

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12 December 2020

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

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12 December 2020

Two strains of the Madin-Darby canine kidney (MDCK) cell line have distinct glycosphingolipid compositions.

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12 December 2020

Caco-2 monolayers in experimental and theoretical predictions of drug transport

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12 December 2020

MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells

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12 December 2020

Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells

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12 December 2020

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

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12 December 2020

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.

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12 December 2020

Identifiers

DOI

10.1023/A:1016140429238

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23 September 2017

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