(Q40701686)

22 September 2017

title

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2. (English)

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22 September 2017

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22 September 2017

David P Lane

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Dimitris P Xirodimas

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22 September 2017

June Chisholm

series ordinal

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22 September 2017

Joana M S Desterro

series ordinal

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22 September 2017

language of work or name

English

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publication date

1 September 2002

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22 September 2017

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22 September 2017

volume

528

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22 September 2017

issue

1-3

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22 September 2017

page(s)

207-211

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

22 September 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

21 January 2018

1 reference

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SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

SUMO--nonclassical ubiquitin

21 January 2018

1 reference

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Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

1 reference

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SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

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Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

21 January 2018

1 reference

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Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

Protein modification by SUMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903310-0

10.1016/S0014-5793(02)03310-0

7 January 2021

Identifiers

DOI

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22 September 2017

1 reference