(Q40642728)

22 September 2017

title

Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation (English)

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22 September 2017

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Serge Haan

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22 September 2017

Paul Ferguson

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22 September 2017

Ulrike Sommer

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22 September 2017

Meena Hiremath

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22 September 2017

Daniel W McVicar

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22 September 2017

Peter C Heinrich

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22 September 2017

James A Johnston

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22 September 2017

Nicholas A Cacalano

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22 September 2017

language of work or name

English

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publication date

3 June 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

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22 September 2017

page(s)

31972-31979

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Signaling by type I and II cytokine receptors: ten years after

22 September 2017

cites work

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SOCS proteins: negative regulators of cytokine signaling

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The SOCS box: a tale of destruction and degradation

21 January 2018

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Twenty proteins containing a C-terminal SOCS box form five structural classes

21 January 2018

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Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

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A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

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A family of cytokine-inducible inhibitors of signalling

21 January 2018

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

21 January 2018

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

21 January 2018

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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21 January 2018

VHL: a very hip ligase

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303170200

The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

21 January 2018

1 reference

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

21 January 2018

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A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

21 January 2018

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Molecular basis of the VHL hereditary cancer syndrome

21 January 2018

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Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

21 January 2018

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 January 2018

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A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase

21 January 2018

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Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

21 January 2018

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Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain

21 January 2018

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Untangling the ErbB signalling network

21 January 2018

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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TRIM8/GERP RING finger protein interacts with SOCS-1

21 January 2018

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Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

21 January 2018

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Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

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SOCS-3 is an insulin-induced negative regulator of insulin signaling

21 January 2018

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Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor

21 January 2018

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

21 January 2018

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

21 January 2018

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A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor

21 January 2018

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Protein destruction: adapting roles for Cks proteins

21 January 2018

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

21 January 2018

1 reference

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303170200

21 January 2018

Identifiers

DOI

10.1074/JBC.M303170200

1 reference

release_s45ulzgue5gxxgcd3qhxoq5lmy

22 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/s45ulzgue5gxxgcd3qhxoq5lmy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference