(Q40634794)

22 September 2017

title

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones (English)

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22 September 2017

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22 September 2017

Jörg Tatzelt

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22 September 2017

Iris H Henn

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22 September 2017

Penelope C Kay-Jackson

series ordinal

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22 September 2017

Ulrich Heller

series ordinal

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22 September 2017

language of work or name

English

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publication date

12 September 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

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22 September 2017

page(s)

47199-47208

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Geldanamycin restores a defective heat shock response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

An enzyme that removes clathrin coats: purification of an uncoating ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Complex relationship between Parkin mutations and Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

1 reference

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Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Oxidatively modified proteins in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Protein folding and the regulation of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

21 January 2018

The heat-shock proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Protein quality control: triage by chaperones and proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

The Hsp70 and Hsp60 chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Molecular chaperones and the aging process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Regional distribution of Hsp70 in the CNS of young and old food-restricted rats following hyperthermia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Scrapie prions selectively modify the stress response in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Chaperoning brain diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Chaperonin-mediated de novo generation of prion protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Chaperone-supervised conversion of prion protein to its protease-resistant form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Chaperoning brain degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

A novel transactivation domain in parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

Polyglutamine protein aggregates are dynamic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306769200

21 January 2018

Identifiers

DOI

10.1074/JBC.M306769200

1 reference

22 September 2017

1 reference