(Q4044985)

English

Notch receptor 1

mammalian protein found in Homo sapiens

Notch homolog 1, translocation-associated
NOTCH1
notch 1
neurogenic locus notch homolog protein 1
translocation-associated notch protein TAN-1
Receptor, Notch1

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

13 November 2019

UniProt protein ID

Notch-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Neurogenic locus Notch 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Notch, NODP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Notch, NOD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF3454, notch, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

DNA-binding transcription factor activity

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

metal ion binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

chromatin binding

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

protein binding

determination method or standard

28 references

9 May 2019

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Direct inhibition of the NOTCH transcription factor complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch is a direct negative regulator of the DNA-damage response

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch1 augments NF-kappaB activity by facilitating its nuclear retention

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Cyclin C is a haploinsufficient tumour suppressor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

sequence-specific DNA binding

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

protein heterodimerization activity

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

chromatin DNA binding

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

signaling receptor activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

enzyme inhibitor activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

extracellular region

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

4 references

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

Golgi apparatus

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

receptor complex

determination method or standard

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

plasma membrane

determination method or standard

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

MAML1-RBP-Jkappa- ICN1 complex

determination method or standard

1 reference

9 May 2019

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endoplasmic reticulum membrane

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

acrosomal vesicle

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

plasma membrane

determination method or standard

adherens junction

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

apical plasma membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

plasma membrane

determination method or standard

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

biological process

endoderm development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

pulmonary valve morphogenesis

determination method or standard

1 reference

24 April 2018

Mutations in NOTCH1 cause aortic valve disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of endothelial cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of somitogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cell differentiation in spinal cord

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of neuron differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

distal tubule development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of transcription by RNA polymerase II

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

oligodendrocyte differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of stem cell differentiation

determination method or standard

1 reference

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of photoreceptor cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

humoral immune response

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

foregut morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of developmental process

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

animal organ regeneration

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

spermatogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of cardioblast proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

hair follicle morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of neurogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cell population proliferation

determination method or standard

3 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

collecting duct development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of neuroblast proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cilium assembly

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

atrioventricular node development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of myoblast differentiation

determination method or standard

1 reference

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cell fate commitment

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cellular response to follicle-stimulating hormone stimulus

determination method or standard

1 reference

9 May 2019

Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

lung development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of inner ear auditory receptor cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

ventricular septum morphogenesis

determination method or standard

1 reference

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

response to muramyl dipeptide

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

in utero embryonic development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cell death

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531

determination method or standard

heart development

determination method or standard

1 reference

9 May 2019

Identification of de novo mutations and rare variants in hypoplastic left heart syndrome

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

prostate gland epithelium morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

embryonic limb morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

neural tube development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

epidermis development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

transcription initiation from RNA polymerase II promoter

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cell-substrate adhesion

determination method or standard

1 reference

9 May 2019

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of inner ear auditory receptor cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

inflammatory response to antigenic stimulus

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of epithelial cell proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac right ventricle formation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endocardial cushion development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cell fate specification

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of keratinocyte differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of glial cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

glomerular mesangial cell development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

sprouting angiogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

glial cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

cardiac muscle cell proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

neuronal stem cell population maintenance

determination method or standard

1 reference

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cell migration involved in sprouting angiogenesis

determination method or standard

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

compartment pattern specification

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

neuron differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

skeletal muscle cell differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of gene expression

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of viral genome replication

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of epithelial cell proliferation involved in prostate gland development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

branching morphogenesis of an epithelial tube

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of anoikis

determination method or standard

1 reference

9 May 2019

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

Notch signaling involved in heart development

determination method or standard

3 references

1 January 2018

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Mutations in NOTCH1 cause aortic valve disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

apoptotic process involved in embryonic digit morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of cell migration

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

tissue regeneration

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

somatic stem cell division

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of endothelial cell chemotaxis

determination method or standard

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

keratinocyte differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

auditory receptor cell fate commitment

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

response to corticosteroid

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

astrocyte differentiation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of calcium ion-dependent exocytosis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

brain development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of cell population proliferation

determination method or standard

3 references

1 January 2018

Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

mitral valve formation

determination method or standard

1 reference

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

liver development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

forebrain development

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cellular response to vascular endothelial growth factor stimulus

determination method or standard

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

neuron fate commitment

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of epithelial cell proliferation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of Notch signaling pathway

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

left/right axis specification

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

4 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

embryonic hindlimb morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of aorta morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

venous blood vessel morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

Notch signaling pathway

determination method or standard

6 references

8 April 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

8 April 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

8 April 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of gene expression

determination method or standard

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of growth rate

determination method or standard

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of Ras protein signal transduction

determination method or standard

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of transcription of Notch receptor target

determination method or standard

outflow tract morphogenesis

determination method or standard

1 reference

9 May 2019

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

aortic valve morphogenesis

determination method or standard

6 references

1 January 2018

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Mutations in NOTCH1 cause aortic valve disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

coronary sinus valve morphogenesis

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

pulmonary valve morphogenesis

determination method or standard

homeostasis of number of cells within a tissue

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

epithelial to mesenchymal transition

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endocardium development

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endocardium morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

coronary vein morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

aortic valve morphogenesis

determination method or standard

5 references

9 May 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

atrioventricular valve morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

epithelial to mesenchymal transition involved in endocardial cushion formation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endocardial cushion morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac chamber formation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac ventricle morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac atrium morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac right atrium morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac left ventricle morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

ventricular trabecula myocardium morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

growth involved in heart morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cell proliferation involved in heart valve morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cell migration involved in endocardial cushion formation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of extracellular matrix constituent secretion

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

pericardium morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

determination of left/right symmetry

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of cell population proliferation

determination method or standard

negative regulation of cell population proliferation

determination method or standard

negative regulation of cardiac muscle hypertrophy

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of gene expression

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of epithelial to mesenchymal transition

determination method or standard

1 reference

9 May 2019

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of myotube differentiation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

mesenchymal cell development

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of ossification

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of BMP signaling pathway

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of BMP signaling pathway

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of catalytic activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of osteoblast differentiation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of Notch signaling pathway

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of receptor signaling pathway via JAK-STAT

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of astrocyte differentiation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of oligodendrocyte differentiation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of neurogenesis

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac muscle tissue morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of cardiac muscle cell proliferation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of glial cell proliferation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac epithelial to mesenchymal transition

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac septum morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

arterial endothelial cell differentiation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

venous endothelial cell differentiation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

cardiac vascular smooth muscle cell development

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

endocardial cell differentiation

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

vasculogenesis involved in coronary vascular morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

coronary artery morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

heart trabecula morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of cardiac epithelial to mesenchymal transition

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of biomineral tissue development

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of cold-induced thermogenesis

determination method or standard

1 reference

9 May 2019

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

regulation of extracellular matrix assembly

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

positive regulation of apoptotic process involved in morphogenesis

determination method or standard

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

negative regulation of pro-B cell differentiation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

Notch signaling pathway

determination method or standard

7 references

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination method or standard

Gene Atlas image

PBB GE NOTCH1 218902 at fs.png
732 × 530; 11 KB

0 references

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Notch, NODP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Notch, NOD domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Domain of unknown function DUF3454, notch

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P46531

Identifiers

MeSH descriptor ID

subject named as

Receptor, Notch1

0 references

D12.776.543.750.725.500

0 references

D12.776.930.770.500

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000498587

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498587

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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