(Q40437150)

20 September 2017

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title

Neurotrophic factors: from structure-function studies to designing effective therapeutics (English)

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20 September 2017

C F Ibáñez

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20 September 2017

language of work or name

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1 June 1995

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20 September 2017

published in

Trends in Biotechnology

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

217-227

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Trophic factors and neuronal survival

20 September 2017

cites work

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7 January 2021

The changing scene of neurotrophic factors

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Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

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7 January 2021

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary

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7 January 2021

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Neurotrophin-6 is a new member of the nerve growth factor family

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The nerve growth factor family of receptors

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7 January 2021

The role of neurotrophins in the developing nervous system

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Neurotrophic factor therapy for nervous system degenerative diseases

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7 January 2021

The Trk family of neurotrophin receptors

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7 January 2021

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

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Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

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7 January 2021

Nerve growth factor mediates signal transduction through trk homodimer receptors

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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor

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New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor

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Crystal structure of human chorionic gonadotropin

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Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

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7 January 2021

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

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7 January 2021

The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.

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7 January 2021

NGF/BDNF chimeric proteins: analysis of neurotrophin specificity by homolog-scanning mutagenesis

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Neurotrophin-3 acquires NGF-like activity after exchange to five NGF amino acid residues: molecular analysis of the sites in NGF mediating the specific interaction with the NGF high affinity receptor

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Purification and characterisation of a brain-derived neurotrophic factor/neurotrophin-3 (BDNF/NT-3) heterodimer

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7 January 2021

Co-evolution of ligand-receptor pairs

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7 January 2021

Motor neurons find their factors

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Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

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Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo

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The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease

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Nerve growth factor administration protects against experimental diabetic sensory neuropathy

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Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

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The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

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A hot spot of binding energy in a hormone-receptor interface

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7 January 2021

Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule

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7 January 2021

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Identifiers

DOI

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20 September 2017

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