(Q40433984)

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Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs

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Europe PubMed Central

PubMed publication ID

20 September 2017

Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs (English)

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Europe PubMed Central

PubMed publication ID

20 September 2017

apoptotic process

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author name string

Kyle Johnson

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Li Liu

2

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Europe PubMed Central

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20 September 2017

Nazanin Majdzadeh

3

1 reference

Europe PubMed Central

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20 September 2017

Cindy Chavez

4

1 reference

Europe PubMed Central

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20 September 2017

Paul C Chin

5

1 reference

Europe PubMed Central

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20 September 2017

Brad Morrison

6

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Europe PubMed Central

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20 September 2017

Lulu Wang

7

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Jane Park

8

1 reference

Europe PubMed Central

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20 September 2017

Priti Chugh

9

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Europe PubMed Central

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20 September 2017

Hsin-Mei Chen

10

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20 September 2017

Santosh R D'Mello

11

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20 September 2017

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publication date

1 May 2005

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Europe PubMed Central

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20 September 2017

Journal of Neurochemistry

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Europe PubMed Central

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20 September 2017

93

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20 September 2017

3

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20 September 2017

538-548

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Europe PubMed Central

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20 September 2017

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Cell cycle regulation of neuronal apoptosis in development and disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Mitochondrial involvement in the point of no return in neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Untying the regulation of the Raf-1 kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Paradoxical activation of Raf by a novel Raf inhibitor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Characterization of novel inhibitors of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

The discovery of potent cRaf1 kinase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Neuronal apoptosis at the G1/S cell cycle checkpoint

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Apoptosis in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Cyclin-dependent kinases as potential targets to improve stroke outcome.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Inhibition of cyclin-dependent kinases by purine analogues

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Targeting programmed cell death in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB-binding protein and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.03004.X

21 January 2018

Identifiers

10.1111/J.1471-4159.2004.03004.X

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

release_mt5zgsdpbngargemf56a5fxi6e

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https://api.fatcat.wiki/v0/release/mt5zgsdpbngargemf56a5fxi6e

24 November 2022

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20 September 2017

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