(Q40417173)

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Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

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Europe PubMed Central

PubMed publication ID

20 September 2017

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase (English)

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Europe PubMed Central

PubMed publication ID

20 September 2017

Ithan D. Peltan

6

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Europe PubMed Central

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20 September 2017

9

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Bradley T Hyman

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Europe PubMed Central

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20 September 2017

author name string

Alberto Lleó

1

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Europe PubMed Central

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20 September 2017

Elaine Waldron

2

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Europe PubMed Central

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20 September 2017

Christine A F von Arnim

3

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Europe PubMed Central

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20 September 2017

Lauren Herl

4

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Europe PubMed Central

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20 September 2017

Michele M Tangredi

5

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Europe PubMed Central

PubMed publication ID

20 September 2017

Dudley K Strickland

7

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Europe PubMed Central

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20 September 2017

Edward H Koo

8

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Europe PubMed Central

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20 September 2017

Claus U Pietrzik

10

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Europe PubMed Central

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20 September 2017

Oksana Berezovska

11

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Europe PubMed Central

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20 September 2017

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publication date

25 May 2005

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Europe PubMed Central

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20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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20 September 2017

280

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Europe PubMed Central

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20 September 2017

29

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Europe PubMed Central

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20 September 2017

27303-27309

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Europe PubMed Central

PubMed publication ID

20 September 2017

LRP: a multifunctional scavenger and signaling receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Intramembrane proteolysis: theme and variations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413969200

21 January 2018

Identifiers

10.1074/JBC.M413969200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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