(Q40171655)

English

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

scientific article published on 12 February 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 September 2017

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

L-H Meng

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

K W Kohn

2

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Y Pommier

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

language of work or name

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publication date

12 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

26

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

33

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

4806-4816

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Molecular interaction map of the mammalian cell cycle control and DNA repair systems

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

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Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner

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p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

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MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation

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HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

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Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage

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Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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The p53 response to DNA damage

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Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.

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DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells

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Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.

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The p53-Mdm2 module and the ubiquitin system.

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A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

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Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

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Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

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Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Apoptosis induced by topoisomerase inhibitors

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

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DNA replication blockade impairs p53-transactivation

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A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

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Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

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The p53-mdm-2 autoregulatory feedback loop

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The transcriptional targets of p53 in apoptosis control

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

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Identifiers

10.1038/SJ.ONC.1210283

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

ResearchGate publication ID

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