(Q40157263)

18 September 2017

title

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. (English)

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18 September 2017

Karen H Vousden

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18 September 2017

Stephanie Carter

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18 September 2017

Oliver Bischof

series ordinal

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18 September 2017

Anne Dejean

series ordinal

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18 September 2017

publication date

18 March 2007

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18 September 2017

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inferred from page(s)

published in

Nature Cell Biology

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18 September 2017

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18 September 2017

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18 September 2017

page(s)

428-435

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Activation of the p53 tumor suppressor protein

18 September 2017

cites work

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

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A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

1 reference

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

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Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes

21 January 2018

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Monoubiquitin carries a novel internalization signal that is appended to activated receptors

21 January 2018

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Fusing DEDD with ubiquitin changes its intracellular localization and apoptotic potential.

21 January 2018

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Regulation of ubiquitin-binding proteins by monoubiquitination

21 January 2018

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C-terminal ubiquitination of p53 contributes to nuclear export

21 January 2018

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Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

21 January 2018

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Tumor suppressor p53: analysis of wild-type and mutant p53 complexes

21 January 2018

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SUMO-1 modification activates the transcriptional response of p53

21 January 2018

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SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

21 January 2018

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Ubiquitin-binding domains

21 January 2018

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Involvement of PIAS1 in the sumoylation of tumor suppressor p53

21 January 2018

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Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

21 January 2018

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The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis

21 January 2018

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A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis

21 January 2018

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Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation

21 January 2018

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

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The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

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Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

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The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

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Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

21 January 2018

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Phosphorylation of HDM2 by Akt.

21 January 2018

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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

21 January 2018

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Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo

21 January 2018

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7 January 2021

Mechanisms underlying ubiquitination

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7 January 2021

Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking

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7 January 2021

Apoptosis. p53 and PUMA: a deadly duo

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7 January 2021

Identifiers

DOI

10.1038/NCB1562

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18 September 2017

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