(Q40046226)

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Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308.

scientific article published on November 2007

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Europe PubMed Central

PubMed publication ID

16 September 2017

Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308. (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

transmembrane protein

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2

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

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Lishuang Cao

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

Helen E Broomhead

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

Samuel J Fountain

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

R Alan North

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

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publication date

1 November 2007

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Europe PubMed Central

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16 September 2017

Journal of Neuroscience

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

27

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

47

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

12916-12923

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

Selective blocking effects of tropisetron and atropine on recombinant glycine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

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The role of positively charged amino acids in ATP recognition by human P2X(1) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polar residues of the second transmembrane domain influence cation permeability of the ATP-gated P2X(2) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular regions controlling the activity of CNG channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular physiology of P2X receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP modulation of excitatory synapses onto interneurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of calcium ions to P2X channel responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP signaling is crucial for communication from taste buds to gustatory nerves

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition mechanism of the recombinant rat P2X(2) receptor in glial cells by suramin and TNP-ATP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-activated ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular properties of P2X receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purinergic transmission in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biophysics of P2X receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered hippocampal synaptic potentiation in P2X4 knock-out mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of amino acid residues contributing to the pore of a P2X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18032665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4036-07.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673282&resulttype=core&format=json

16 May 2020

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