(Q39942521)

15 September 2017

title

Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. (English)

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15 September 2017

Joseph M Gozgit

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15 September 2017

Geraldine Bebernitz

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15 September 2017

Pankaj Patil

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15 September 2017

Minwei Ye

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15 September 2017

Julie Parmentier

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15 September 2017

Jiaquan Wu

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15 September 2017

Nancy Su

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15 September 2017

Tao Wang

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15 September 2017

Stephanos Ioannidis

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15 September 2017

Audrey Davies

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15 September 2017

Dennis Huszar

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15 September 2017

Michael Zinda

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15 September 2017

language of work or name

English

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publication date

4 September 2008

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Journal of Biological Chemistry

15 September 2017

published in

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15 September 2017

volume

283

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15 September 2017

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15 September 2017

page(s)

32334-32343

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Janus kinases: components of multiple signaling pathways

15 September 2017

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Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes.

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Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis

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The survival kinases Akt and Pim as potential pharmacological targets

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The serine/threonine kinase Pim-1

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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

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Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

21 January 2018

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

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Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

21 January 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

21 January 2018

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Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

21 January 2018

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

21 January 2018

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

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Pharmacological manipulation of cell death: clinical applications in sight?

21 January 2018

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

21 January 2018

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

21 January 2018

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Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes

21 January 2018

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Activated Jak2 with the V617F point mutation promotes G1/S phase transition

21 January 2018

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JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders

21 January 2018

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Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles

21 January 2018

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Expression of Bcl-x in erythroid precursors from patients with polycythemia vera

21 January 2018

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JAK2 V617F: implications for thrombosis in myeloproliferative diseases

21 January 2018

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

21 January 2018

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JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling

21 January 2018

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Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M803813200

1 reference

15 September 2017

1 reference