(Q39599916)

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Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease.

scientific article published on January 2002

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9 December 2019

Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease (English)

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9 December 2019

Alzheimer's disease

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William J. Anderson

3

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9 December 2019

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R G Nagele

1

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9 December 2019

M R D'Andrea

2

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9 December 2019

H-Y Wang

4

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9 December 2019

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1 January 2002

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9 December 2019

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9 December 2019

110

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9 December 2019

2

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9 December 2019

199-211

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9 December 2019

Cellular expression of alpha7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease--a stereological approach

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Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain

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Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

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Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients.

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Neuron loss in APP transgenic mice

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

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The alpha-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the alpha7 subunit

1 reference

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7 January 2021

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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7 January 2021

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A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1 reference

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7 January 2021

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Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

1 reference

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7 January 2021

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Postmortem stability of alpha-bungarotoxin binding sites in mouse and human brain.

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Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization

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Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

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Intraneuronal Abeta42 accumulation in human brain.

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7 January 2021

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Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease

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7 January 2021

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Amyloid, the presenilins and Alzheimer's disease

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Rapid cellular uptake of Alzheimer amyloid betaA4 peptide by cultured human neuroblastoma cells

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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The cholinergic system in Alzheimer's disease

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The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).

1 reference

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7 January 2021

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Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

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Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells

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https://api.crossref.org/works/10.1016%2FS0306-4522%2801%2900460-2

7 January 2021

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Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer

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Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

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Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors

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Human nicotinic receptors--their role in aging and dementia

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Neuronal nicotinic receptors in the human brain

1 reference

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Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line

1 reference

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inferred from DOI database lookup

beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

1 reference

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Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein

1 reference

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inferred from DOI database lookup

Nicotinic receptors and neurodegenerative dementing diseases: basic research and clinical implications.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0306-4522(01)00460-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11958863%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11958863%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

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