(Q39519625)

English

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

scientific article published on 22 June 2011

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5 February 2020

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation (English)

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5 February 2020

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Fabrizio Manetti

8

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5 February 2020

Federico Falchi

2

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5 February 2020

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5 February 2020

Hamid Irannejad

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5 February 2020

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5 February 2020

Stefania Paolucci

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5 February 2020

Fausto Baldanti

16

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5 February 2020

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5 February 2020

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Giovanni Maga

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ORCID Public Data File 2021

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Maurizio Botta

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5 February 2020

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Lorenzo Botta

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5 February 2020

Gianni Casaluce

5

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5 February 2020

Martina Bernardini

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5 February 2020

Anna Garbelli

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5 February 2020

Alberta Samuele

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5 February 2020

Samantha Zanoli

11

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5 February 2020

Emmanuel Gonzalez

13

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5 February 2020

Elisa Zucca

14

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5 February 2020

Jan De Rijck

17

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5 February 2020

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22 June 2011

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5 February 2020

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5 February 2020

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5 February 2020

8

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5 February 2020

1371-1389

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5 February 2020

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication

1 reference

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21 January 2018

Host determinants in HIV infection and disease. Part 2: genetic factors and implications for antiretroviral therapeutics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Viral and cellular RNA helicases as antiviral targets

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays

1 reference

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21 January 2018

Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP

1 reference

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21 January 2018

Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication

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Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives

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Recent highlights in the synthesis of highly functionalized pyrimidines

1 reference

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A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs

1 reference

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21 January 2018

Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines

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LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

1 reference

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21 January 2018

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100166

21 January 2018

Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites

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Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms

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Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.

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Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown

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LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin

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Upscaling of lentiviral vector production by tangential flow filtration

1 reference

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21 January 2018

Genome-scale RNAi screen for host factors required for HIV replication

1 reference

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A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues

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7 January 2021

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Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

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7 January 2021

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