(Q39211265)

10 September 2017

Metabolism. Differential regulation of mTORC1 by leucine and glutamine (English)

1 reference

10 September 2017

Vincent S. Tagliabracci

object named as

Vincent S Tagliabracci

1 reference

10 September 2017

Jenna L Jewell

1 reference

10 September 2017

Young Chul Kim

1 reference

10 September 2017

Ryan C Russell

1 reference

10 September 2017

Fa-Xing Yu

1 reference

10 September 2017

Hyun Woo Park

1 reference

10 September 2017

Steven W Plouffe

1 reference

10 September 2017

Kun-Liang Guan

1 reference

10 September 2017

language of work or name

English

0 references

publication date

7 January 2015

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10 September 2017

1 reference

inferred from page(s)

published in

Science

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10 September 2017

347

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10 September 2017

6218

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10 September 2017

194-198

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Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Nutrient signaling to mTOR and cell growth

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Amino acid signalling upstream of mTOR

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

RNA-guided human genome engineering via Cas9

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Multiplex genome engineering using CRISPR/Cas systems

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

mTOR signaling in growth control and disease

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Regulation of mTORC1 by the Rab and Arf GTPases

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Bidirectional transport of amino acids regulates mTOR and autophagy

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Regulation of TORC1 by Rag GTPases in nutrient response

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

ARF proteins: roles in membrane traffic and beyond

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Amino acid availability regulates p70 S6 kinase and multiple translation factors

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

Glutaminolysis activates Rag-mTORC1 signaling.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384888

RNA interference of gene expression (RNAi) in cultured Drosophila cells.

21 August 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

RNA-programmed genome editing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

Amino acid transport across mammalian intestinal and renal epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1259472

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1259472

1 reference

release_3cwma3xktbczpjkzfsnbxiy64e

10 September 2017

0 references

1 reference

10 September 2017

PubMed publication ID

25567907

1 reference