(Q38363888)

2 September 2017

title

Chk1 signaling pathways that mediated G(2)M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350. (English)

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2 September 2017

Ming-biao Yin

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2 September 2017

Gunnar Hapke

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2 September 2017

Jiaxi Wu

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2 September 2017

Rami G Azrak

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2 September 2017

Cheryl Frank

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2 September 2017

Carol Wrzosek

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2 September 2017

Youcef M Rustum

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2 September 2017

language of work or name

English

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publication date

1 July 2002

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Biochemical and Biophysical Research Communications

2 September 2017

published in

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2 September 2017

volume

295

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2 September 2017

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2 September 2017

page(s)

435-444

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The current status of camptothecin analogues as antitumor agents

2 September 2017

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Lowered phosphorylation of topoisomerase I is a direct reason for reduced sensitivity of L5178Y-S cells to camptothecin

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Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

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Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast

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Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage

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The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

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Mechanisms of resistance to N-[5-[N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

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Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

7 January 2021

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

7 January 2021

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

7 January 2021

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

7 January 2021

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UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

7 January 2021

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UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

7 January 2021

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7 January 2021

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The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast

7 January 2021

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Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

7 January 2021

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An essential phosphorylation-site domain of human cdc25C interacts with both 14-3-3 and cyclins.

7 January 2021

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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

7 January 2021

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10.1016/S0006-291X(02)00683-6

7 January 2021

Identifiers

DOI

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2 September 2017

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