(Q38359958)

2 September 2017

title

A two-drug model for etoposide action against human topoisomerase IIalpha (English)

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2 September 2017

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Neil Osheroff

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2 September 2017

Alex B Burgin

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2 September 2017

Kenneth D Bromberg

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2 September 2017

language of work or name

English

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publication date

8 December 2002

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Journal of Biological Chemistry

2 September 2017

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inferred from page(s)

published in

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2 September 2017

volume

278

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2 September 2017

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2 September 2017

page(s)

7406-7412

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Etoposide: four decades of development of a topoisomerase II inhibitor

2 September 2017

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Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

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Structure of DNA topoisomerases

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Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

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Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

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Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase

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The critical role of chromosome translocations in human leukemias.

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Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

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Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

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Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism

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Positioning the 3'-DNA terminus for topoisomerase II-mediated religation

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

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Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

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Maternal diet and infant leukemia: A role for DNA topoisomerase II inhibitors?

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Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.

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Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV.

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Identification of active site residues in the "GyrA" half of yeast DNA topoisomerase II.

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21 January 2018

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Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

21 January 2018

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Type II DNA topoisomerase from Saccharomyces cerevisiae is a stable dimer

21 January 2018

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21 January 2018

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21 January 2018

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Differential in vitro interactions of a series of clinically useful topoisomerase-interacting compounds with the cleavage/religation activity of the human topoisomerase IIalpha and IIbeta isoforms

21 January 2018

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Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

21 January 2018

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DNA cleavage and religation by human topoisomerase II alpha at high temperature

21 January 2018

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Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance

21 January 2018

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Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

21 January 2018

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Translating the knowledge of molecular alterations that occur during colon carcinogenesis into clinically relevant solutions

21 January 2018

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The response of eukaryotic topoisomerases to DNA damage

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M212056200

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2 September 2017

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