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MEKK1/JNK signaling stabilizes and activates p53.
scientific article published on September 1998
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1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
title
MEKK1/JNK signaling stabilizes and activates p53
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
author
Zeev Ronai
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
author name string
S Y Fuchs
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
V Adler
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
M R Pincus
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
language of work or name
English
0 references
publication date
1 September 1998
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
published in
Proceedings of the National Academy of Sciences of the United States of America
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
volume
95
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
issue
18
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
page(s)
10541-10546
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
cites work
DNA damage induces phosphorylation of the amino terminus of p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors
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PubMed Central
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23 August 2017
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
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PubMed Central
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23 August 2017
p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs
1 reference
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PubMed Central
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23 August 2017
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
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PubMed Central
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Regulation of p53 stability by Mdm2
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PubMed Central
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23 August 2017
Mdm2 promotes the rapid degradation of p53
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PubMed Central
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23 August 2017
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity
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PubMed Central
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23 August 2017
Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C
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PubMed Central
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23 August 2017
Conformation-dependent phosphorylation of p53.
1 reference
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PubMed Central
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23 August 2017
p53, the cellular gatekeeper for growth and division
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PubMed Central
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23 August 2017
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
1 reference
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PubMed Central
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23 August 2017
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.
1 reference
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PubMed Central
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23 August 2017
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
p53 and E2F-1 cooperate to mediate apoptosis
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PubMed Central
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23 August 2017
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
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23 August 2017
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Transcription factor ATF2 regulation by the JNK signal transduction pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Production of high-titer helper-free retroviruses by transient transfection
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Complexes of p21RAS with JUN N-terminal kinase and JUN proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Phosphorylation sites in the amino-terminal region of mouse p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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23 August 2017
JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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6 September 2017
UV irradiation and heat shock mediate JNK activation via alternate pathways.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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6 September 2017
Biochemical properties and biological effects of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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14 September 2017
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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28 September 2017
Sounding the alarm: protein kinase cascades activated by stress and inflammation
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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28 September 2017
Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
retrieved
28 September 2017
p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
retrieved
28 September 2017
Mdm2 association with p53 targets its ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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26 June 2018
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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26 June 2018
Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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26 June 2018
On the multiple-minima problem in the conformational analysis of polypeptides. II. An electrostatically driven Monte Carlo method--tests on poly(L-alanine).
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
retrieved
26 June 2018
Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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26 June 2018
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
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2 September 2018
An osmosensing signal transduction pathway in mammalian cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
retrieved
2 September 2018
Small peptides activate the latent sequence-specific DNA binding function of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27930
retrieved
2 September 2018
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9724739
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9724739
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.95.18.10541
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
ADS bibcode
1998PNAS...9510541F
0 references
PMC publication ID
27930
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
PubMed publication ID
9724739
1 reference
stated in
Europe PubMed Central
PMC publication ID
27930
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9724739%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
ResearchGate publication ID
13560393
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