(Q37231726)

19 August 2017

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title

The endoplasmic reticulum stress response in immunity and autoimmunity (English)

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19 August 2017

main subject

endoplasmic reticulum

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Ann-Hwee Lee

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19 August 2017

Laurie H Glimcher

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19 August 2017

Derrich J Todd

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19 August 2017

publication date

1 September 2008

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Nature Reviews Immunology

19 August 2017

published in

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19 August 2017

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19 August 2017

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19 August 2017

page(s)

663-674

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

19 August 2017

cites work

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

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In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis

21 January 2018

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Spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated transcription factors

21 January 2018

1 reference

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

21 January 2018

1 reference

High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis

21 January 2018

1 reference

Uniquely conformed peptide-containing beta 2-microglobulin-free heavy chains of HLA-B2705 on the cell surface

21 January 2018

1 reference

Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.

21 January 2018

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The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis

21 January 2018

1 reference

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

21 January 2018

1 reference

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

31 March 2020

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

31 March 2020

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

31 March 2020

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

31 March 2020

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

31 March 2020

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

31 March 2020

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

31 March 2020

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

31 March 2020

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Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

31 March 2020

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

31 March 2020

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Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

31 March 2020

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Cloning of mammalian Ire1 reveals diversity in the ER stress responses

31 March 2020

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Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

31 March 2020

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The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

31 March 2020

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Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

31 March 2020

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

31 March 2020

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

31 March 2020

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Autophagy is activated for cell survival after endoplasmic reticulum stress

31 March 2020

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

31 March 2020

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Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

31 March 2020

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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

31 March 2020

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Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

31 March 2020

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pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

31 March 2020

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

31 March 2020

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A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

31 March 2020

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The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core

31 March 2020

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XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

31 March 2020

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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

31 March 2020

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Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

31 March 2020

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The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology

31 March 2020

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

31 March 2020

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

31 March 2020

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

31 March 2020

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Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

31 March 2020

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

31 March 2020

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The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

31 March 2020

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

31 March 2020

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Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response

31 March 2020

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

31 March 2020

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Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

31 March 2020

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Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction

31 March 2020

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ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum

31 March 2020

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Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

31 March 2020

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ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

31 March 2020

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

31 March 2020

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

31 March 2020

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The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

31 March 2020

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Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response.

31 March 2020

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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

31 March 2020

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Identification of ERdj3 and OBF-1/BOB-1/OCA-B as direct targets of XBP-1 during plasma cell differentiation

31 March 2020

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Regulation of hepatic lipogenesis by the transcription factor XBP1

31 March 2020

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XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

31 March 2020

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Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

31 March 2020

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P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

31 March 2020

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

31 March 2020

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Plasma cell differentiation requires the transcription factor XBP-1

31 March 2020

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

31 March 2020

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Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

31 March 2020

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RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

31 March 2020

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Activation of an unfolded protein response during differentiation of antibody-secreting B cells.

31 March 2020

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XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells

31 March 2020

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Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate.

31 March 2020

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Biogenesis of the endoplasmic reticulum in activated B lymphocytes: temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid.

31 March 2020

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Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately

31 March 2020

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The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

31 March 2020

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The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

31 March 2020

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Origins and functions of B-1 cells with notes on the role of CD5

31 March 2020

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TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses

31 March 2020

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Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

31 March 2020

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Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

31 March 2020

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

31 March 2020

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Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

31 March 2020

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Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation

31 March 2020

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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

31 March 2020

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Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

31 March 2020

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An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

31 March 2020

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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

31 March 2020

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Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation

31 March 2020

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The transcription factor XBP-1 is essential for the development and survival of dendritic cells

31 March 2020

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CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

31 March 2020

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Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

31 March 2020

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Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders

31 March 2020

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HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum

31 March 2020

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HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease

31 March 2020

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Pathogenesis of ankylosing spondylitis: current concepts

31 March 2020

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An initial blueprint for myogenic differentiation

31 March 2020

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XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

31 March 2020

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Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract

31 March 2020

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Activation of the endoplasmic reticulum stress response in autoimmune myositis: Potential role in muscle fiber damage and dysfunction

31 March 2020

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Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies

31 March 2020

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The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis

31 March 2020

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Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity

31 March 2020

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Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

31 March 2020

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The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

31 March 2020

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Inflammation, atherosclerosis, and coronary artery disease

31 March 2020

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Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis

31 March 2020

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The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

31 March 2020

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

31 March 2020

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Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy

31 March 2020

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Rheumatoid arthritis as a hyper-endoplasmic-reticulum-associated degradation disease

31 March 2020

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Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis

31 March 2020

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Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats

31 March 2020

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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

31 March 2020

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The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

31 March 2020

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Endoplasmic reticulum stress signaling in disease

31 March 2020

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Multiple myeloma: charging toward a bright future.

31 March 2020

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31 March 2020

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

31 March 2020

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Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2359

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Dimensions Publication ID

19 August 2017

1032995817

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