(Q36918634)

17 August 2017

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title

Cancer and ageing: convergent and divergent mechanisms (English)

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17 August 2017

Manuel Serrano

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Maria A Blasco

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1 September 2007

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Nature Reviews Molecular Cell Biology

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

715-722

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INK4a/ARF: a multifunctional tumor suppressor locus

17 August 2017

cites work

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21 January 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

Cellular senescence in cancer and aging

31 March 2020

1 reference

Evolution, stress, and longevity

31 March 2020

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Oxidative phosphorylation and aging

31 March 2020

1 reference

Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging

31 March 2020

1 reference

Sirtuins as potential targets for metabolic syndrome

31 March 2020

1 reference

Extended longevity in mice lacking the insulin receptor in adipose tissue

31 March 2020

1 reference

Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention

31 March 2020

1 reference

Calorie restriction, SIRT1 and metabolism: understanding longevity

31 March 2020

1 reference

Therapeutic potential of resveratrol: the in vivo evidence

31 March 2020

1 reference

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

31 March 2020

1 reference

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

31 March 2020

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

31 March 2020

1 reference

Resveratrol improves health and survival of mice on a high-calorie diet

31 March 2020

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

31 March 2020

1 reference

Suppression of aging in mice by the hormone Klotho

31 March 2020

1 reference

FOXO transcription factors at the interface between longevity and tumor suppression

31 March 2020

1 reference

Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis

31 March 2020

1 reference

Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans

31 March 2020

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Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer

31 March 2020

1 reference

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

31 March 2020

1 reference

Oxidative damage to mitochondria and aging

31 March 2020

1 reference

Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

31 March 2020

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Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

31 March 2020

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Extension of murine life span by overexpression of catalase targeted to mitochondria

31 March 2020

1 reference

Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.

31 March 2020

1 reference

Oxidative stress and aging: beyond correlation

31 March 2020

1 reference

Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points

31 March 2020

1 reference

The antioxidant function of the p53 tumor suppressor

31 March 2020

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Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice

31 March 2020

1 reference

Coping with stress: multiple ways to activate p53.

31 March 2020

1 reference

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

31 March 2020

1 reference

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

1 reference

p53 in health and disease

31 March 2020

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

31 March 2020

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Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

31 March 2020

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Tumor suppression and normal aging in mice with constitutively high p53 activity

31 March 2020

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Delayed ageing through damage protection by the Arf/p53 pathway

31 March 2020

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p53 mutant mice that display early ageing-associated phenotypes

31 March 2020

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Modulation of mammalian life span by the short isoform of p53.

31 March 2020

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Mutations that increase the life span of C. elegans inhibit tumor growth.

31 March 2020

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DNA repair, genome stability, and aging

31 March 2020

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Telomeres and human disease: ageing, cancer and beyond

31 March 2020

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Shelterin: the protein complex that shapes and safeguards human telomeres

31 March 2020

1 reference

The epigenetic regulation of mammalian telomeres

31 March 2020

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Telomerase in the human organism

31 March 2020

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Homologous recombination generates T-loop-sized deletions at human telomeres

31 March 2020

1 reference

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

31 March 2020

1 reference

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

31 March 2020

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Cellular senescence in aging primates.

31 March 2020

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Telomerase therapeutics for cancer: challenges and new directions

31 March 2020

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

31 March 2020

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Effects of telomerase and telomere length on epidermal stem cell behavior

31 March 2020

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Conditional telomerase induction causes proliferation of hair follicle stem cells

31 March 2020

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The first molecular details of ALT in human tumor cells

31 March 2020

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

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Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

31 March 2020

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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

31 March 2020

1 reference

Association between telomere length in blood and mortality in people aged 60 years or older

31 March 2020

1 reference

High-throughput telomere length quantification by FISH and its application to human population studies

31 March 2020

1 reference

Telomere length regulation during postnatal development and ageing in Mus spretus

31 March 2020

1 reference

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

31 March 2020

1 reference

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

31 March 2020

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Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Putting the stress on senescence

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

1 reference

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

31 March 2020

1 reference

BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

1 reference

Ink4a/Arf expression is a biomarker of aging

31 March 2020

1 reference

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

31 March 2020

1 reference

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

31 March 2020

1 reference

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

31 March 2020

1 reference

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

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p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

31 March 2020

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Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

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Complicating the role of p53 in aging.

31 March 2020

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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

31 March 2020

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

31 March 2020

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

31 March 2020

1 reference

Genomic instability in laminopathy-based premature aging

31 March 2020

1 reference

Telomerase regulation and stem cell behaviour

31 March 2020

1 reference

Increased p53 activity does not accelerate telomere-driven ageing

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM2242

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Dimensions Publication ID

17 August 2017

1033612140

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1 reference