(Q36867350)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Marica Bordicchia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Chaoying Zhang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Huafeng Fang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Wan Wei

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Jian-Liang Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Adilson Guilherme

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Kalyani Guntur

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Michael P Czech

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Sheila Collins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

language of work or name

English

0 references

publication date

28 March 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

31 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

volume

126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

page(s)

1704-1716

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

31 March 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4855937/fullTextXML

inferred from PubMed Central ID database lookup

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Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

29 September 2017

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Lessons on conditional gene targeting in mouse adipose tissue

29 September 2017

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29 September 2017

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

29 September 2017

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A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods

29 September 2017

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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

29 September 2017

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A unifying model for mTORC1-mediated regulation of mRNA translation.

29 September 2017

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

29 September 2017

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Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

29 September 2017

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Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

29 September 2017

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

29 September 2017

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Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

29 September 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

29 September 2017

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mTOR: from growth signal integration to cancer, diabetes and ageing

29 September 2017

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A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes

29 September 2017

1 reference

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cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

29 September 2017

1 reference

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

29 September 2017

1 reference

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Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression

29 September 2017

1 reference

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Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

29 September 2017

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

29 September 2017

1 reference

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High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity

29 September 2017

1 reference

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Functional brown adipose tissue in healthy adults

29 September 2017

1 reference

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Identification and importance of brown adipose tissue in adult humans

29 September 2017

1 reference

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

29 September 2017

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

29 September 2017

1 reference

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Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Location, location: protein trafficking and lipolysis in adipocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Defining the role of mTOR in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Unexpected evidence for active brown adipose tissue in adult humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

TOR signaling in growth and metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Growing roles for the mTOR pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Transduction of receptor signals by beta-arrestins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Brown adipose tissue: function and physiological significance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Mechanism of activation of protein kinase B by insulin and IGF-1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Fat cell adrenergic receptors and the control of white and brown fat cell function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Molecular mechanisms involved in the antilipolytic action of insulin: phosphorylation and activation of a particulate adipocyte cAMP phosphodiesterase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

An established pre-adipose cell line and its differentiation in culture.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Development of brown and white adipose tissue

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Increased brown adipose tissue oxidative capacity in cold-acclimated humans

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855937

Neural influences on trophic changes in brown adipose tissue during cold acclimation

4 September 2018

1 reference

12 December 2020

Beta-adrenergic stimulation of brown adipocyte proliferation

1 reference

12 December 2020

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

1 reference

12 December 2020

Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia

1 reference

12 December 2020

Insulin signaling in the adipocyte

1 reference

12 December 2020

Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats

1 reference

12 December 2020

Role of sympathetic innervation in brown adipocyte proliferation

1 reference

12 December 2020

Convertible adipose tissue in mice

1 reference

12 December 2020

Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin)

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI83532

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

PubMed publication ID

27018708

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018708%20AND%20SRC:MED&resulttype=core&format=json