(Q36844392)

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Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures

scientific article published on 3 April 2007

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scholarly article

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Europe PubMed Central

PMC publication ID

16 August 2017

Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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6

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Yves Pommier

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Europe PubMed Central

16 August 2017

PMC publication ID

author name string

Andrew Morrell

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Michael S Placzek

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Jamin D Steffen

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Smitha Antony

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Keli Agama

5

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Europe PubMed Central

PMC publication ID

16 August 2017

Mark Cushman

7

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Europe PubMed Central

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16 August 2017

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publication date

3 April 2007

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Europe PubMed Central

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16 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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16 August 2017

50

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Europe PubMed Central

PMC publication ID

16 August 2017

9

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Europe PubMed Central

PMC publication ID

16 August 2017

2040-2048

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Europe PubMed Central

PMC publication ID

16 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2519145/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519145

29 September 2017

Topoisomerase I inhibitors: camptothecins and beyond

1 reference

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29 September 2017

Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors

1 reference

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29 September 2017

Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay

1 reference

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29 September 2017

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

1 reference

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29 September 2017

Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

1 reference

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29 September 2017

An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes

1 reference

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29 September 2017

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

1 reference

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29 September 2017

Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings

1 reference

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29 September 2017

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

1 reference

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29 September 2017

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors

1 reference

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29 September 2017

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen

1 reference

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29 September 2017

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

1 reference

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29 September 2017

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

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29 September 2017

DNA topoisomerases: structure, function, and mechanism

1 reference

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Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

1 reference

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29 September 2017

Intermittent exposure of medulloblastoma cells to topotecan produces growth inhibition equivalent to continuous exposure.

1 reference

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29 September 2017

Kinetics of anthracycline accumulation in multidrug-resistant tumor cells: relationship to drug lipophilicity and serum albumin binding

1 reference

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29 September 2017

Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

1 reference

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29 September 2017

DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519145

29 September 2017

New colorimetric cytotoxicity assay for anticancer-drug screening

1 reference

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29 September 2017

Inhibition of Reverse Transcriptase Activity by Benzophenanthridine Alkaloids

1 reference

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29 September 2017

Clinical applications of the camptothecins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519145

27 June 2018

Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride

1 reference

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27 June 2018

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1 reference

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27 June 2018

Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors

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5 September 2018

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

1 reference

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5 September 2018

Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I

1 reference

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5 September 2018

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids

1 reference

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5 September 2018

Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model

1 reference

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Synthesis and biological activity of some antitumor benzophenanthridinium salts

1 reference

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12 December 2020

based on heuristic

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Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

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inferred from PubMed ID database lookup

Equilibrium binding of anthracycline cytostatics to serum albumin and small unilamellar phospholipid vesicles as measured by gel filtration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

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inferred from PubMed ID database lookup

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

12 December 2020

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inferred from PubMed ID database lookup

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

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Limited sampling model for area under the concentration time curve of total topotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

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inferred from PubMed ID database lookup

Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17402722

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM0613119

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

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