(Q36759577)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

review article

1 reference

title

Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Waza M

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Katsuno M

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Tanaka F

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Doyu M

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Sobue G

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

publication date

1 April 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

Neuropathology and Applied Neurobiology

27 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

page(s)

135-151

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17359355%20AND%20SRC:MED&resulttype=core&format=json

Hiroshi Kawahara (1858-1918).

27 December 2019

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21 January 2018

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Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene

21 January 2018

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21 January 2018

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

21 January 2018

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Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy

21 January 2018

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Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

21 January 2018

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Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization

21 January 2018

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Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

21 January 2018

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Isolation of a novel population of multipotent adult stem cells from human hair follicles

21 January 2018

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Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

21 January 2018

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21 January 2018

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Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

21 January 2018

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Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: a pathogenic marker

21 January 2018

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Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor

21 January 2018

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Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

21 January 2018

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21 January 2018

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p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

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Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

21 January 2018

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Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

21 January 2018

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Effect of geldanamycin on androgen receptor function and stability

21 January 2018

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

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Geldanamycin provides posttreatment protection against glutamate-induced oxidative toxicity in a mouse hippocampal cell line

21 January 2018

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Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons

21 January 2018

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21 January 2018

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Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation

21 January 2018

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

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Evidence for glucocorticoid receptor transport on microtubules by dynein.

21 January 2018

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FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.

21 January 2018

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Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction

21 January 2018

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Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

21 January 2018

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Therapeutic and diagnostic implications of Hsp90 activation

21 January 2018

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Modulation of neurodegeneration by molecular chaperones

21 January 2018

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

1 reference

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

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Targeting toxic proteins for turnover

21 January 2018

1 reference

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

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Inefficient degradation of truncated polyglutamine proteins by the proteasome

21 January 2018

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Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

21 January 2018

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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

21 January 2018

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

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Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

21 January 2018

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Sick chaperones, cellular stress, and disease

21 January 2018

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Role of chaperones in nuclear translocation and transactivation of steroid receptors

21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

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Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

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Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis

21 January 2018

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

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Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

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Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

21 January 2018

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Chaperones increase association of tau protein with microtubules

21 January 2018

1 reference

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

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Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X

Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2990.2007.00830.X