(Q36599922)

15 August 2017

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title

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development (English)

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15 August 2017

Gord Fishell

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15 August 2017

Marc Fuccillo

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15 August 2017

Alexandra L Joyner

series ordinal

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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Nature Reviews Neuroscience

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

772-783

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

15 August 2017

cites work

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Hedgehog signaling in animal development: paradigms and principles

31 March 2020

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Neuronal specification in the spinal cord: inductive signals and transcriptional codes

31 March 2020

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The interpretation of morphogen gradients

31 March 2020

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

31 March 2020

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All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

31 March 2020

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

31 March 2020

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

31 March 2020

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A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

31 March 2020

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Altered neural cell fates and medulloblastoma in mouse patched mutants

31 March 2020

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Biochemical evidence that patched is the Hedgehog receptor

31 March 2020

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

31 March 2020

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Patched acts catalytically to suppress the activity of Smoothened

31 March 2020

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Small molecule modulation of Smoothened activity

31 March 2020

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The Hedgehog response network: sensors, switches, and routers

31 March 2020

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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

31 March 2020

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A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo

31 March 2020

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

31 March 2020

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Cilia and Hedgehog responsiveness in the mouse

31 March 2020

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Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

31 March 2020

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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

31 March 2020

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Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification

31 March 2020

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Vertebrate Smoothened functions at the primary cilium

31 March 2020

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

31 March 2020

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The neuronal primary cilium--an extrasynaptic signaling device

31 March 2020

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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

31 March 2020

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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

31 March 2020

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

31 March 2020

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The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types

31 March 2020

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Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

31 March 2020

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An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

31 March 2020

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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

31 March 2020

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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

31 March 2020

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The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling.

31 March 2020

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The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish

31 March 2020

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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

31 March 2020

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The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

31 March 2020

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The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

31 March 2020

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Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly

31 March 2020

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Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

31 March 2020

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Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

31 March 2020

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Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

31 March 2020

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A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

31 March 2020

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Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

31 March 2020

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Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

31 March 2020

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A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

31 March 2020

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Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

31 March 2020

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A Requirement for Retinoic Acid-Mediated Transcriptional Activation in Ventral Neural Patterning and Motor Neuron Specification

31 March 2020

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A dual role for Sonic hedgehog in regulating adhesion and differentiation of neuroepithelial cells

31 March 2020

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Temporal requirement for hedgehog signaling in ventral telencephalic patterning.

31 March 2020

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

31 March 2020

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Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon

31 March 2020

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LRP2/megalin is required for patterning of the ventral telencephalon

31 March 2020

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Megalin functions as an endocytic sonic hedgehog receptor

31 March 2020

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Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

31 March 2020

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Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling

31 March 2020

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FGF signalling generates ventral telencephalic cells independently of SHH.

31 March 2020

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Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression

31 March 2020

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Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development

31 March 2020

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Hedgehog signaling from the ZLI regulates diencephalic regional identity

31 March 2020

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Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant.

31 March 2020

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A role for midbrain arcs in nucleogenesis

31 March 2020

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Signals from the ventral midline and isthmus regulate the development of Brn3.0-expressing neurons in the midbrain

31 March 2020

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FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate

31 March 2020

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Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

31 March 2020

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Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

31 March 2020

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Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum

31 March 2020

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

31 March 2020

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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

31 March 2020

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The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

31 March 2020

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Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog

31 March 2020

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Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: effects of notochord and floor plate grafts, and of sonic hedgehog

31 March 2020

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Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system

31 March 2020

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Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors

31 March 2020

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Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

31 March 2020

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The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

31 March 2020

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Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors

31 March 2020

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Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro

31 March 2020

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Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells

31 March 2020

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Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.

31 March 2020

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Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

31 March 2020

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Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors

31 March 2020

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Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

31 March 2020

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Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

31 March 2020

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The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

31 March 2020

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Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog

31 March 2020

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Making the connection: retinal axon guidance in the zebrafish

31 March 2020

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Expression and regulation of a netrin homologue in the zebrafish embryo.

31 March 2020

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Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain

31 March 2020

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The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

31 March 2020

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Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord.

31 March 2020

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

31 March 2020

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

31 March 2020

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

31 March 2020

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Genetic inducible fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system

31 March 2020

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In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

31 March 2020

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

31 March 2020

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Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation

31 March 2020

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Splitting the Hedgehog signal: sex and patterning in Drosophila

31 March 2020

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Dual roles for patched in sequestering and transducing Hedgehog

31 March 2020

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Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex

31 March 2020

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SONIC HEDGEHOG mutations causing human holoprosencephaly impair neural patterning activity

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN1990

1 reference

15 August 2017

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