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Lipid modification of secreted signaling proteins.
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1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
Lipid modification of secreted signaling proteins
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
author
Jessica E Treisman
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
author name string
Grant I Miura
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
publication date
1 June 2006
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
number of pages
5
1 reference
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inferred from page(s)
published in
Cell Cycle
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
volume
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
issue
11
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
page(s)
1184-1188
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms
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Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine
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30 September 2017
Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
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30 September 2017
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30 September 2017
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
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30 September 2017
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface
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Secreted antagonists of the Wnt signalling pathway
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Wnt proteins are lipid-modified and can act as stem cell growth factors
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30 September 2017
Signaling by the Drosophila epidermal growth factor receptor pathway during development
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30 September 2017
The on-off story of protein palmitoylation
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PubMed Central
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30 September 2017
Similarities between the Hedgehog and Wnt signaling pathways
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PubMed Central
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30 September 2017
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
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30 September 2017
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
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30 September 2017
A freely diffusible form of Sonic hedgehog mediates long-range signalling
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30 September 2017
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
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PubMed Central
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30 September 2017
Enhanced potency of human Sonic hedgehog by hydrophobic modification.
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30 September 2017
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
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PubMed Central
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30 September 2017
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
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PubMed Central
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30 September 2017
Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity.
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30 September 2017
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
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30 September 2017
Identification of a palmitic acid-modified form of human Sonic hedgehog
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PubMed Central
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30 September 2017
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
1 reference
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PubMed Central
reference URL
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30 September 2017
branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
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30 September 2017
Dual roles for patched in sequestering and transducing Hedgehog
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30 September 2017
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
1 reference
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PubMed Central
reference URL
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30 September 2017
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
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30 September 2017
The endocytic pathway and formation of the Wingless morphogen gradient
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
28 June 2018
A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
28 June 2018
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
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28 June 2018
Signal dynamics in Sonic hedgehog tissue patterning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
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21 September 2018
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Model organisms lead the way to protein palmitoyltransferases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Producing cells retain and recycle Wingless in Drosophila embryos.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2725518
retrieved
21 September 2018
Identifiers
DOI
10.4161/CC.5.11.2804
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
PMC publication ID
2725518
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
PubMed publication ID
16721064
1 reference
stated in
Europe PubMed Central
PMC publication ID
2725518
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16721064%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
ResearchGate publication ID
7061780
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