(Q36403372)

14 August 2017

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title

ILK, PINCH and parvin: the tIPP of integrin signalling (English)

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14 August 2017

Reinhard Fässler

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14 August 2017

Oliver Kudlacek

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14 August 2017

Kyle R Legate

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14 August 2017

Eloi Montañez

series ordinal

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14 August 2017

publication date

1 January 2006

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Nature Reviews Molecular Cell Biology

14 August 2017

published in

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

20-31

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Integrins: bidirectional, allosteric signaling machines

14 August 2017

cites work

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Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans

31 March 2020

1 reference

Consequences of lack of beta 1 integrin gene expression in mice

31 March 2020

1 reference

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality

31 March 2020

1 reference

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

31 March 2020

1 reference

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

31 March 2020

1 reference

Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation.

31 March 2020

1 reference

A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

31 March 2020

1 reference

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction

31 March 2020

1 reference

A new LIM protein containing an autoepitope homologous to "senescent cell antigen"

31 March 2020

1 reference

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

31 March 2020

1 reference

A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans

31 March 2020

1 reference

Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration

31 March 2020

1 reference

PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions

31 March 2020

1 reference

Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion

31 March 2020

1 reference

Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.

31 March 2020

1 reference

Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival.

31 March 2020

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Phosphorylation of actopaxin regulates cell spreading and migration

31 March 2020

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Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans

31 March 2020

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Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival

31 March 2020

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Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

31 March 2020

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PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

31 March 2020

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Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival

31 March 2020

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Consequences of loss of PINCH2 expression in mice

31 March 2020

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A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration

31 March 2020

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Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

31 March 2020

1 reference

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

31 March 2020

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Analysis of PINCH function inDrosophilademonstrates its requirement in integrin-dependent cellular processes

31 March 2020

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PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions

31 March 2020

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Paxillin: a new vinculin-binding protein present in focal adhesions

31 March 2020

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The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.

31 March 2020

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Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome

31 March 2020

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Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation

31 March 2020

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The many faces of filamin: a versatile molecular scaffold for cell motility and signalling

31 March 2020

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Ectopic expression of Rsu-1 results in elevation of p21CIP and inhibits anchorage-independent growth of MCF7 breast cancer cells

31 March 2020

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The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.

31 March 2020

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The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions

31 March 2020

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Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

31 March 2020

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PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes

31 March 2020

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Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling

31 March 2020

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Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility

31 March 2020

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The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

31 March 2020

1 reference

Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

31 March 2020

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Transcriptional activation of the c-fos gene by a LIM protein, Hic-5.

31 March 2020

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A LIM protein, Hic-5, functions as a potential coactivator for Sp1.

31 March 2020

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Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin

31 March 2020

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Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction

31 March 2020

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Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

31 March 2020

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

31 March 2020

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

31 March 2020

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AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading

31 March 2020

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Calpain-mediated proteolysis of talin regulates adhesion dynamics

31 March 2020

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Dysferlin interacts with affixin (beta-parvin) at the sarcolemma

31 March 2020

1 reference

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

31 March 2020

1 reference

Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury

31 March 2020

1 reference

Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes

31 March 2020

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A novel role for integrin-linked kinase in epithelial sheet morphogenesis

31 March 2020

1 reference

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

31 March 2020

1 reference

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

31 March 2020

1 reference

Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase

31 March 2020

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Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

31 March 2020

1 reference

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.

31 March 2020

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ILKAP regulates ILK signaling and inhibits anchorage-independent growth

31 March 2020

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Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

31 March 2020

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Integrin-linked kinase regulates chondrocyte shape and proliferation

31 March 2020

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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

31 March 2020

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Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth

31 March 2020

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

31 March 2020

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Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization

31 March 2020

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The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner

31 March 2020

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Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

31 March 2020

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The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP

31 March 2020

1 reference

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

31 March 2020

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CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt

31 March 2020

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Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

31 March 2020

1 reference

Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway

31 March 2020

1 reference

C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo

31 March 2020

1 reference

The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane

31 March 2020

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Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes

31 March 2020

1 reference

The control of cell motility and epithelial morphogenesis by Jun kinases

31 March 2020

1 reference

The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility

31 March 2020

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Genetic analysis of protein kinase B (AKT) in Drosophila

31 March 2020

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Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination

31 March 2020

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Role of integrin-linked kinase in leukocyte recruitment.

31 March 2020

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Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

31 March 2020

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Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes

31 March 2020

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Integrin-linked kinase regulates endothelial cell survival and vascular development.

31 March 2020

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Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons

31 March 2020

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Inactivation of Integrin-linked Kinase Induces Aberrant Tau Phosphorylation via Sustained Activation of Glycogen Synthase Kinase 3β in N1E-115 Neuroblastoma Cells

31 March 2020

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Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

31 March 2020

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Integrin-actin interactions

31 March 2020

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Xenopus ILK (integrin-linked kinase) is required for morphogenetic movements during gastrulation

31 March 2020

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The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

31 March 2020

1 reference

Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.

31 March 2020

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The anti-apoptotic role of PPARβ contributes to efficient skin wound healing

31 March 2020

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The role of integrin-linked kinase (ILK) in cancer progression

31 March 2020

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

31 March 2020

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Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells

31 March 2020

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Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

31 March 2020

1 reference

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

31 March 2020

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

31 March 2020

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Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

31 March 2020

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Atm-deficient mice: a paradigm of ataxia telangiectasia

31 March 2020

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

31 March 2020

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The role of laminin in embryonic cell polarization and tissue organization

31 March 2020

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Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion

31 March 2020

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Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.

31 March 2020

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Haspin: a mitotic histone kinase required for metaphase chromosome alignment

31 March 2020

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The protein kinase complement of the human genome

31 March 2020

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Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner

31 March 2020

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Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase

31 March 2020

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Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency

31 March 2020

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Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase

31 March 2020

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Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases

31 March 2020

1 reference

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1789

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Dimensions Publication ID

14 August 2017

1036759909

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