(Q36379365)

13 August 2017

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title

Targeting chaperones in transformed systems--a focus on Hsp90 and cancer (English)

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13 August 2017

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Gabriela Chiosis

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language of work or name

English

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publication date

1 February 2006

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Expert Opinion on Therapeutic Targets

13 August 2017

published in

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

37-50

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Imatinib as a paradigm of targeted therapies

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Epidermal growth factor receptor inhibitors and their role in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Targeting multiple signal transduction pathways through inhibition of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90: the vulnerable chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

HSP90 and the chaperoning of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp70 and Hsp90--a relay team for protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Structure and functional relationships of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

ATPases as drug targets: learning from their structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

GHKL, an emergent ATPase/kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Development of Radicicol Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 inhibitors identified from a library of novobiocin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Modulating molecular chaperone Hsp90 functions through reversible acetylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, a

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Rational design of shepherdin, a novel anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Functional specificity of co-chaperone interactions with Hsp90 client proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Natural Product Origins of Hsp90 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 as a capacitor for morphological evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 as a capacitor of phenotypic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Regulation of survivin function by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Telomere maintenance and tumorigenesis: an "ALT"ernative road

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hypoxia inducible factor-1: a novel target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Genes and Proteins Governing the Cellular Sensitivity to HSP90 Inhibitors: A Mechanistic Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Heat shock proteins increase resistance to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Escaping cell death: survival proteins in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Mechanisms of apoptosis avoidance in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Molecular chaperones and the stress of oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Downstream caspases are novel targets for the antiapoptotic activity of the molecular chaperone hsp70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Hsp90 is essential in the filarial nematode Brugia pahangi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.37

21 January 2018

Identifiers

DOI

10.1517/14728222.10.1.37

1 reference

13 August 2017

1 reference