(Q36080916)

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Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

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Europe PubMed Central

PMC publication ID

12 August 2017

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines (English)

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Europe PubMed Central

PMC publication ID

12 August 2017

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Jackman AL

1

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Europe PubMed Central

PMC publication ID

12 August 2017

Kelland LR

2

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Europe PubMed Central

PMC publication ID

12 August 2017

Kimbell R

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Brown M

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Gibson W

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Aherne GW

6

1 reference

Europe PubMed Central

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12 August 2017

Hardcastle A

7

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Europe PubMed Central

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12 August 2017

Boyle FT

8

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Europe PubMed Central

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12 August 2017

language of work or name

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publication date

1 May 1995

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Europe PubMed Central

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12 August 2017

British Journal of Cancer

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12 August 2017

71

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Europe PubMed Central

PMC publication ID

12 August 2017

5

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Europe PubMed Central

PMC publication ID

12 August 2017

914-924

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Europe PubMed Central

PMC publication ID

12 August 2017

describes a project that uses

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Thymidylate Synthetase Overproduction in 5-Fluorodeoxyuridine-Resistant Mouse Fibroblasts

1 reference

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2 October 2017

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

1 reference

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2 October 2017

A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.

1 reference

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2 October 2017

Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes

1 reference

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2 October 2017

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

2 October 2017

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

1 reference

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2 October 2017

Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma

1 reference

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2 October 2017

Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).

1 reference

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11 July 2018

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitoR, ICI D1694, in mouse and human cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Mechanisms of acquired resistance to methotrexate in a human squamous carcinoma cell line of the head and neck, exposed to different treatment schedules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Human lymphoblastoid cells with acquired resistance to C2-desamino-C2-methyl-N10-propargyl-5,8-dideazafolic acid: a novel folate-based thymidylate synthase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Enzyme studies of methotrexate-resistant human leukemic cell (K562) subclones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

11 July 2018

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

23 September 2018

A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

23 September 2018

Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033796

23 September 2018

Human thymidylate synthetase--III. Effects of methotrexate and folate analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of thymidylate synthase gene amplification and of mRNA levels in the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The quantitation by radioimmunoassay of 2′-deoxyuridine 5′-triphosphate in extracts of thymidylate synthase-inhibited cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.1995.178

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Europe PubMed Central

PMC publication ID

12 August 2017

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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