(Q35879915)

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Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

scientific article published on 5 January 2012

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Europe PubMed Central

PMC publication ID

10 August 2017

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics (English)

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Europe PubMed Central

PMC publication ID

10 August 2017

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Nathanael S Gray

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Europe PubMed Central

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10 August 2017

Peter K. Sorger

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Peter K Sorger

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10 August 2017

David M. Sabatini

20

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David M Sabatini

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10 August 2017

14

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Takaomi Sanda

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10 August 2017

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A Thomas Look

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10 August 2017

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Qingsong Liu

1

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10 August 2017

Sivapriya Kirubakaran

2

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10 August 2017

Wooyoung Hur

3

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10 August 2017

Mario Niepel

4

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10 August 2017

Kenneth Westover

5

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10 August 2017

Carson C Thoreen

6

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10 August 2017

Jinhua Wang

7

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10 August 2017

Jing Ni

8

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10 August 2017

Matthew P Patricelli

9

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10 August 2017

Kurt Vogel

10

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10 August 2017

Steve Riddle

11

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10 August 2017

David L Waller

12

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10 August 2017

Ryan Traynor

13

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10 August 2017

Zheng Zhao

15

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10 August 2017

Seong A Kang

16

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10 August 2017

Jean Zhao

17

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10 August 2017

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publication date

5 January 2012

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10 August 2017

Journal of Biological Chemistry

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10 August 2017

287

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10 August 2017

13

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10 August 2017

9742-9752

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Europe PubMed Central

PMC publication ID

10 August 2017

Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin

1 reference

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Adaptive informatics for multifactorial and high-content biological data

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Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

1 reference

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mTOR Mediated Anti-Cancer Drug Discovery

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Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

1 reference

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11 July 2018

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

1 reference

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11 July 2018

Optimal targeting of the mTORC1 kinase in human cancer

1 reference

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11 July 2018

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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11 July 2018

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

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Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

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11 July 2018

Functional interrogation of the kinome using nucleotide acyl phosphates

1 reference

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Drug-target residence time and its implications for lead optimization

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11 July 2018

Rational design of inhibitors that bind to inactive kinase conformations

1 reference

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11 July 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

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11 July 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

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PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways

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SWISS-MODEL: An automated protein homology-modeling server

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

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Two adenovirus mRNAs have a common 5' terminal leader sequence encoded at least 10 kb upstream from their main coding regions

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Identifiers

10.1074/JBC.M111.304485

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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