(Q35857474)

10 August 2017

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title

Back to the future: the 'old-fashioned' way to new medications for neurodegeneration (English)

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10 August 2017

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Peter T Lansbury

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10 August 2017

language of work or name

English

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publication date

1 July 2004

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10 August 2017

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10 August 2017

volume

10 Suppl

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10 August 2017

page(s)

S51-7

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Diagnostic evaluation of elderly patients with mild memory problems

10 August 2017

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1 reference

Alzheimer's disease and Parkinson's disease

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

31 March 2020

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A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

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ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onset.

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Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions

31 March 2020

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Looking backwards: a possible new path for drug discovery in psychopharmacology

31 March 2020

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A common origin for cosmic explosions inferred from calorimetry of GRB030329

31 March 2020

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Apoptosis in the nervous system

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Pathways to Parkinsonism

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

31 March 2020

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

31 March 2020

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

31 March 2020

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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Anti-inflammatory drugs and Alzheimer disease.

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

31 March 2020

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The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

31 March 2020

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

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A portrait of Alzheimer secretases--new features and familiar faces

31 March 2020

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Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

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A Drosophila model of Parkinson's disease

31 March 2020

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Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

31 March 2020

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Pharmacological prevention of Parkinson disease in Drosophila.

31 March 2020

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

31 March 2020

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Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

31 March 2020

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Systematic discovery of multicomponent therapeutics

31 March 2020

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Drug development. Biotech thinking comes to academic medical centers

31 March 2020

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A new model for drug discovery--meeting our societal obligation

31 March 2020

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Dementia with Lewy bodies

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN1435

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Dimensions Publication ID

1052531504

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1 reference