(Q35730286)

9 August 2017

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title

Tracing the network connecting BRCA and Fanconi anaemia proteins (English)

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9 August 2017

Ashok R Venkitaraman

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9 August 2017

language of work or name

English

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publication date

1 April 2004

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9 August 2017

published in

Nature Reviews Cancer

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

266-276

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

9 August 2017

cites work

1 reference

Cancer susceptibility and the functions of BRCA1 and BRCA2

31 March 2020

1 reference

Homologous repair of DNA damage and tumorigenesis: the BRCA connection

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The Fanconi anaemia/BRCA pathway

31 March 2020

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31 March 2020

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Breast cancer genetics: what we know and what we need

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Variation in cancer risks, by mutation position, in BRCA2 mutation carriers

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Cancer Incidence in BRCA1 mutation carriers

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High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium

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Biallelic inactivation of BRCA2 in Fanconi anemia

31 March 2020

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Fanconi's anemia and malignancies

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Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes

31 March 2020

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The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG

31 March 2020

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A novel ubiquitin ligase is deficient in Fanconi anemia

31 March 2020

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FANCE: the link between Fanconi anaemia complex assembly and activity

31 March 2020

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The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC

31 March 2020

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

31 March 2020

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

31 March 2020

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Involvement of Brca2 in DNA repair

31 March 2020

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

31 March 2020

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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

31 March 2020

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The emerging genetic and molecular basis of Fanconi anaemia

31 March 2020

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Molecular views of recombination proteins and their control

31 March 2020

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Brca1 controls homology-directed DNA repair

31 March 2020

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BRCA2 is required for homology-directed repair of chromosomal breaks

31 March 2020

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Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

31 March 2020

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Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

31 March 2020

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Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

31 March 2020

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BRCA2 deficiency in mice leads to meiotic impairment and infertility

31 March 2020

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Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells

31 March 2020

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Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

31 March 2020

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Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia

31 March 2020

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The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange

31 March 2020

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Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs

31 March 2020

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RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

31 March 2020

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The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

31 March 2020

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Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

31 March 2020

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

31 March 2020

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Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2

31 March 2020

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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

31 March 2020

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Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

31 March 2020

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31 March 2020

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

31 March 2020

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Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

31 March 2020

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

31 March 2020

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

31 March 2020

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Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1.

31 March 2020

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

31 March 2020

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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

31 March 2020

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BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks

31 March 2020

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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

31 March 2020

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Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1

31 March 2020

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

31 March 2020

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Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50

31 March 2020

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The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression

31 March 2020

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BRCA1 is a component of the RNA polymerase II holoenzyme

31 March 2020

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BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

31 March 2020

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BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

31 March 2020

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BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

31 March 2020

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BRCA1 supports XIST RNA concentration on the inactive X chromosome

31 March 2020

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

31 March 2020

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Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

31 March 2020

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

31 March 2020

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BRCA1 interacts directly with the Fanconi anemia protein FANCA

31 March 2020

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BRCA1-independent ubiquitination of FANCD2

31 March 2020

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Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

31 March 2020

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Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

31 March 2020

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Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

31 March 2020

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Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein

31 March 2020

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A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

31 March 2020

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

31 March 2020

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Interaction of FANCD2 and NBS1 in the DNA damage response

31 March 2020

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

31 March 2020

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Damage-resistant DNA synthesis in Fanconi anemia cells treated with a DNA cross-linking agent

31 March 2020

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Arrest of S-phase progression is impaired in Fanconi anemia cells

31 March 2020

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DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links.

31 March 2020

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The importance of repairing stalled replication forks

31 March 2020

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Recombinational repair and restart of damaged replication forks.

31 March 2020

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DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae

31 March 2020

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Post-replication repair in DT40 cells: translesion polymerases versus recombinases

31 March 2020

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Error-prone repair DNA polymerases in prokaryotes and eukaryotes

31 March 2020

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

31 March 2020

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Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

31 March 2020

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Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A.

31 March 2020

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Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus

31 March 2020

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Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

31 March 2020

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Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates

31 March 2020

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Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1321

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9 August 2017

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