(Q35620073)

9 August 2017

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title

Dendritic cells: emerging pharmacological targets of immunosuppressive drugs (English)

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9 August 2017

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Angus W Thomson

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9 August 2017

Holger Hackstein

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9 August 2017

publication date

1 January 2004

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Nature Reviews Immunology

9 August 2017

published in

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

24-34

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Drug-induced Immunological Tolerance

9 August 2017

cites work

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The effects of 6-mercaptopurine on homograft reactions

31 March 2020

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Transplantation tolerance from a historical perspective

31 March 2020

1 reference

Immunobiology of dendritic cells

31 March 2020

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Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells

31 March 2020

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The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells

31 March 2020

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Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development

31 March 2020

1 reference

Glucocorticoids down‐regulate dendritic cell function in vitro and in vivo

31 March 2020

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Recruitment of CD1a+ Langerhans cells to the nasal mucosa in seasonal allergic rhinitis and effects of topical corticosteroid therapy

31 March 2020

1 reference

Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids

31 March 2020

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Corticosteroids depress IFN-alpha-producing plasmacytoid dendritic cells in human blood

31 March 2020

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Early differentiation of thymic dendritic cells in the absence of glucocorticoids

31 March 2020

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1,25-Dihydroxyvitamin D(3) inhibits dendritic cell differentiation and maturation in vitro

31 March 2020

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1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation

31 March 2020

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Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells

31 March 2020

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Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs

31 March 2020

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Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo

31 March 2020

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Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells

31 March 2020

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Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages

31 March 2020

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Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

31 March 2020

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Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages

31 March 2020

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Rapamycin impairs antigen uptake of human dendritic cells

31 March 2020

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Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

31 March 2020

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Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

31 March 2020

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A closer look at proteolysis and MHC-class-II-restricted antigen presentation.

31 March 2020

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Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways

31 March 2020

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Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation

31 March 2020

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Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells

31 March 2020

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Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells

31 March 2020

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Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets

31 March 2020

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Selective proteasome inhibitors: modulators of antigen presentation?

31 March 2020

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

31 March 2020

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The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

31 March 2020

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An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

31 March 2020

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Rapamycin inhibits proteasome activator expression and proteasome activity

31 March 2020

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A role for the proteasome regulator PA28alpha in antigen presentation

31 March 2020

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Antigen conformation determines processing requirements for T-cell activation

31 March 2020

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Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

31 March 2020

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

31 March 2020

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Controlled trial with chloroquine diphosphate in systemic lupus erythematosus.

31 March 2020

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Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites

31 March 2020

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Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming

31 March 2020

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Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

31 March 2020

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Inhibition by dexamethasone of Langerhans cell migration: influence of epidermal cytokine signals

31 March 2020

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Distinctive dendritic cell modulation by vitamin D(3) and glucocorticoid pathways.

31 March 2020

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Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo

31 March 2020

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Unique regulation of CCL18 production by maturing dendritic cells

31 March 2020

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Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators

31 March 2020

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A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

31 March 2020

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

31 March 2020

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A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo

31 March 2020

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Alterations of dendritic cells in the rat thymus without epithelial cell loss during cyclosporine treatment and recovery

31 March 2020

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Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets

31 March 2020

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Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells

31 March 2020

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Designer dendritic cells for tolerance induction: guided not misguided missiles

31 March 2020

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Differential effects of corticosteroids during different stages of dendritic cell maturation

31 March 2020

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Flow cytometrically-sorted residual HLA-DR+T6+ Langerhans cells in topical steroid-treated human skin express normal amounts of HLA-DR and CD1a/T6 antigens and exhibit normal alloantigen-presenting capacity

31 March 2020

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Manipulating immune responses with immunosuppressive agents that target NFAT.

31 March 2020

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Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: association with reduced nuclear translocation of nuclear factor kappa B.

31 March 2020

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Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus

31 March 2020

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Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells.

31 March 2020

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Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation

31 March 2020

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Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action

31 March 2020

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Cutting edge: sanglifehrin A, a novel cyclophilin-binding immunosuppressant blocks bioactive IL-12 production by human dendritic cells.

31 March 2020

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Mycophenolate mofetil impairs the maturation and function of murine dendritic cells

31 March 2020

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Cyclooxygenase-independent inhibition of dendritic cell maturation by aspirin

31 March 2020

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Aspirin differentially regulates endotoxin-induced IL-12 and TNF-alpha production in human dendritic cells

31 March 2020

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Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo

31 March 2020

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MHC class II and CD40 play opposing roles in dendritic cell survival.

31 March 2020

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Potential of tolerogenic dendritic cells for transplantation

31 March 2020

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Tolerogenic dendritic cells

31 March 2020

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Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity.

31 March 2020

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Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells

31 March 2020

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A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

31 March 2020

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Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

31 March 2020

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Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

31 March 2020

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Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts

31 March 2020

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Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

31 March 2020

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Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

31 March 2020

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Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.

31 March 2020

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Interleukin-10-treated dendritic cells modulate immune responses of naive and sensitized T cells in vivo

31 March 2020

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CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity

31 March 2020

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Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin

31 March 2020

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LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity

31 March 2020

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Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells1

31 March 2020

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Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides

31 March 2020

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Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10

31 March 2020

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Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse

31 March 2020

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Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells

31 March 2020

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Tolerance, DCs and tryptophan: much ado about IDO

31 March 2020

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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

31 March 2020

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Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.

31 March 2020

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The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocortical hormone in arthritis: preliminary report

31 March 2020

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THE REJECTION OF RENAL HOMOGRAFTS

31 March 2020

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Prolonged survival of human-kidney homografts by immunosuppressive drug therapy

31 March 2020

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The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type

31 March 2020

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Biological effects of cyclosporin A: A new antilymphocytic agent

31 March 2020

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Cyclosporin A in patients receiving renal allografts from cadaver donors

31 March 2020

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FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

31 March 2020

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FK 506 for liver, kidney, and pancreas transplantation

31 March 2020

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

31 March 2020

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Inhibition of the immune response by rapamycin, a new antifungal antibiotic

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1256

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9 August 2017

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