(Q35564185)

8 August 2017

1 reference

title

The von Hippel-Lindau gene, kidney cancer, and oxygen sensing (English)

1 reference

8 August 2017

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing (English)

1 reference

10.1097/01.ASN.0000092803.69761.41

Crossref

DOI

https://api.crossref.org/works/10.1097/01.ASN.0000092803.69761.41

23 March 2024

1 reference

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14569079

23 March 2024

1 reference

10.1097/01.ASN.0000092803.69761.41

https://api.crossref.org/works/10.1097/01.ASN.0000092803.69761.41

23 March 2024

William G Kaelin

1 reference

8 August 2017

language of work or name

1 reference

1 November 2003

1 reference

Journal of the American Society of Nephrology

8 August 2017

published in

1 reference

8 August 2017

1 reference

8 August 2017

1 reference

8 August 2017

page(s)

2703-2711

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

8 August 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

Mutations of the VHL tumour suppressor gene in renal carcinoma

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NG0594-85

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Vascular endothelial growth factor expression is increased in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Comparative sequence analysis of the VHL tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Characterization and comparative analysis of the EGLN gene family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Differential response to transforming growth factor (TGF)-alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Expression of Vascular Endothelial Growth Factor in Capillary Hemangioblastoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Rapamycin is an effective inhibitor of human renal cancer metastasis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Von Hippel-Lindau tumour suppressor gene. Localization of expression by in situ hybridization

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Mosaicism in von Hippel-Lindau disease: lessons from kindreds with germline mutations identified in offspring with mosaic parents

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Polycythemia: mechanisms and management

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Mutation and cancer: statistical study of retinoblastoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The role of iron and 2-oxoglutarate oxygenases in signalling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

von Hippel-Lindau disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Über eine sehr seltene Erkrankung der Netzhaut

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNFalpha cytotoxicity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

A general theory of carcinogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Protein tyrosine kinase inhibitors: new treatment modalities?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1097/01.ASN.0000092803.69761.41

Identifiers

DOI

10.1097/01.ASN.0000092803.69761.41

1 reference

release_yvkwbegefrdlpg5jhvdit6al3e

8 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yvkwbegefrdlpg5jhvdit6al3e

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference