(Q35551155)

8 August 2017

title

Pharmacogenomics: road to anticancer therapeutics nirvana? (English)

1 reference

8 August 2017

1 reference

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206958

18 March 2024

Mark J Ratain

1 reference

8 August 2017

Federico Innocenti

1 reference

8 August 2017

Apurva A. Desai

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14528287

18 March 2024

language of work or name

English

0 references

publication date

1 September 2003

1 reference

8 August 2017

29 September 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14528287

full work available at URL

18 March 2024

https://www.nature.com/articles/1206958.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14528287

https://www.nature.com/articles/1206958.pdf

18 March 2024

file format

Portable Document Format

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.ONC.1206958

https://www.nature.com/articles/1206958

18 March 2024

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.ONC.1206958

18 March 2024

1 reference

8 August 2017

1 reference

8 August 2017

1 reference

8 August 2017

page(s)

6621-6628

1 reference

Epidermal growth factor receptors

8 August 2017

cites work

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Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy

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Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

21 January 2018

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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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Molecular genetic basis of Gilbert's syndrome

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Two chromosome 7 dinucleotide repeat polymorphisms at gene loci epidermal growth factor receptor (EGFR) and pro alpha 2 (I) collagen (COL1A2)

21 January 2018

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Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase

21 January 2018

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Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck

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Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer

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Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1.

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Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies

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Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene

21 January 2018

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Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

21 January 2018

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The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer

21 January 2018

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Clinical trial designs for cytostatic agents: are new approaches needed?

21 January 2018

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Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin

21 January 2018

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Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival

21 January 2018

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Pharmacogenetics in cancer treatment

21 January 2018

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Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer

21 January 2018

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Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells

21 January 2018

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Epidermal growth factor-related peptides and their receptors in human malignancies

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Development of target-based antineoplastic agents

21 January 2018

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Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

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Irinotecan in the treatment of colorectal cancer: clinical overview

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Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

21 January 2018

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Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity

21 January 2018

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7 January 2021

Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11.

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7 January 2021

Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

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7 January 2021

Receptors for epidermal growth factor and other polypeptide mitogens

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7 January 2021

Chromatin structure of the EGFR gene suggests a role for intron 1 sequences in its regulation in breast cancer cells

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7 January 2021

Genetic variations in the acetylation of isoniazid and other drugs

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7 January 2021

Pharmacogenomics: translating functional genomics into rational therapeutics

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7 January 2021

Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy: progression from reversible to irreversible inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Update on pharmacogenetics in cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Clinical pharmacology of camptothecins.

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7 January 2021

Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA.

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7 January 2021

Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations

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7 January 2021

Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

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7 January 2021

Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles

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7 January 2021

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Novel thymidylate synthase enhancer region alleles in African populations

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells

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7 January 2021

Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line

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7 January 2021

UGT1*1 genotyping in a Canadian Inuit population

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2, ERB B3) in colorectal adenocarcinomas and adenomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Gazing into a crystal ball-cancer therapy in the post-genomic era

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

The genetic basis of Gilbert's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206958

7 January 2021

Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206958

Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected].

18 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206958

18 March 2024

Identifiers

DOI

1 reference

8 August 2017

1 reference