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English
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.
scientific article published on October 2003
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
main subject
proteolysis
1 reference
based on heuristic
inferred from title
neurodegeneration
1 reference
based on heuristic
inferred from title
author
Robert Layfield
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
James Lowe
0 references
author name string
James R Cavey
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
James Lowe
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
language of work or name
English
1 reference
based on heuristic
inferred from title
publication date
1 October 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
published in
Ageing Research Reviews
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
volume
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
issue
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
page(s)
343-356
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
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Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
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alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining
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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
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Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro
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Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions
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Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease
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Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.
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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice
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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
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Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains
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Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.
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7 January 2021
based on heuristic
inferred from DOI database lookup
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal
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Crossref
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7 January 2021
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inferred from DOI database lookup
Does an inhibition of the ubiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?
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The ubiquitin protein catabolic disorders.
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7 January 2021
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Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells
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Neurodegenerative tauopathies
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7 January 2021
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The ubiquitin pathway in Parkinson's disease
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7 January 2021
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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
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Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility
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Endoproteolytic activity of the proteasome
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7 January 2021
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Defective ubiquitination of cerebral proteins in Alzheimer's disease
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
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Quality control of mRNA function
1 reference
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7 January 2021
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Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.
1 reference
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7 January 2021
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De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal function is impaired in substantia nigra in Parkinson's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered proteasomal function in sporadic Parkinson's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin is a component of paired helical filaments in Alzheimer's disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How the ubiquitin-proteasome system controls transcription
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha-synuclein in Lewy bodies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of the polyubiquitin proteolytic signal
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
+1 Proteins and aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900025-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1568-1637(03)00025-4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
PubMed publication ID
14522239
1 reference
stated in
Europe PubMed Central
PubMed publication ID
14522239
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14522239%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 December 2019
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