(Q35214758)

7 August 2017

title

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression (English)

1 reference

7 August 2017

0 references

0 references

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Frederick Dobie

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Weihong Song

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Matthias Staufenbiel

1 reference

7 August 2017

Xiulian Sun

1 reference

7 August 2017

Guiqiong He

1 reference

7 August 2017

Hong Qing

1 reference

7 August 2017

Weihui Zhou

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7 August 2017

Fang Cai

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7 August 2017

L Eric Huang

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7 August 2017

language of work or name

English

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publication date

22 November 2006

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Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

published in

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7 August 2017

volume

103

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7 August 2017

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7 August 2017

page(s)

18727-18732

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BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

7 August 2017

cites work

1 reference

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Effects of anoxia and hypoxia on amyloid precursor protein processing in cerebral microvascular smooth muscle cells

13 July 2018

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Leaky scanning and reinitiation regulate BACE1 gene expression

13 July 2018

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Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription

13 July 2018

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Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

13 July 2018

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The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

13 July 2018

1 reference

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Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center

13 July 2018

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Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways

13 July 2018

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Pathways towards and away from Alzheimer's disease

13 July 2018

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Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

13 July 2018

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Gene regulation and DNA damage in the ageing human brain

13 July 2018

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HIF1 and oxygen sensing in the brain

13 July 2018

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BACE (beta-secretase) modulates the processing of APLP2 in vivo

13 July 2018

1 reference

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Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

13 July 2018

1 reference

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

13 July 2018

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Beta-secretase activity increases with aging in human, monkey, and mouse brain.

13 July 2018

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Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

13 July 2018

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Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

13 July 2018

1 reference

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Regulation of angiogenesis by hypoxia: role of the HIF system

13 July 2018

1 reference

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Relation of cerebral infarctions to dementia and cognitive function in older persons

13 July 2018

1 reference

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Hypoxia-inducible factor and its biomedical relevance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Temporal profile of neuronal damage in a model of transient forebrain ischemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Delayed poststroke dementia: a 4-year follow-up study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Silent brain infarcts and the risk of dementia and cognitive decline

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Presenilin-1 mutations in Alzheimer's disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

26 September 2018

Hydergine for dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693730

15 November 2018

Identifiers

DOI

10.1073/PNAS.0606298103

1 reference

7 August 2017

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1 reference

7 August 2017

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