(Q35209992)

7 August 2017

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title

Therapeutic antagonists and conformational regulation of integrin function (English)

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7 August 2017

Motomu Shimaoka

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7 August 2017

Timothy A Springer

series ordinal

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7 August 2017

publication date

1 September 2003

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Nature Reviews Drug Discovery

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

703-716

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Integrins: versatility, modulation, and signaling in cell adhesion

7 August 2017

cites work

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Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

31 March 2020

1 reference

Conformational regulation of integrin structure and function

31 March 2020

1 reference

31 March 2020

1 reference

Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents

31 March 2020

1 reference

Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

31 March 2020

1 reference

Novel platelet inhibitors

31 March 2020

1 reference

Modulating T cell responses for the treatment of psoriasis: a focus on efalizumab

31 March 2020

1 reference

Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy

31 March 2020

1 reference

Alpha 4 integrin antagonists

31 March 2020

1 reference

Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents

31 March 2020

1 reference

The discovery of VLA-4 antagonists

31 March 2020

1 reference

Crystal structure of the extracellular segment of integrin alpha Vbeta3

31 March 2020

1 reference

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

31 March 2020

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C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

31 March 2020

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

31 March 2020

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Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

31 March 2020

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Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

31 March 2020

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Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

31 March 2020

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Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain

31 March 2020

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The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

31 March 2020

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A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding

31 March 2020

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

31 March 2020

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

31 March 2020

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

31 March 2020

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Structural basis of collagen recognition by integrin alpha2beta1

31 March 2020

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Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit

31 March 2020

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

31 March 2020

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Integrin activation and structural rearrangement

31 March 2020

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Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).

31 March 2020

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Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

31 March 2020

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High affinity ligand binding by integrins does not involve head separation

31 March 2020

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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

31 March 2020

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

31 March 2020

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Does the integrin alphaA domain act as a ligand for its betaA domain?

31 March 2020

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Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.

31 March 2020

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

31 March 2020

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Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

31 March 2020

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A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

31 March 2020

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Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

31 March 2020

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Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

31 March 2020

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Structure/function analysis of the integrin beta 1 subunit by epitope mapping

31 March 2020

1 reference

Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium

31 March 2020

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Structural interlock between ligand-binding site and stalk-like region of beta1 integrin revealed by a monoclonal antibody recognizing conformation-dependent epitope

31 March 2020

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

31 March 2020

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Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

31 March 2020

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Determination of kinetic constants for the interaction between the platelet glycoprotein IIb-IIIa and fibrinogen by means of surface plasmon resonance

31 March 2020

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Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets

31 March 2020

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Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: a novel approach to study integrins

31 March 2020

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Unusually stable and long-lived ligand-induced conformations of integrins

31 March 2020

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Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated

31 March 2020

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Intrinsic activating properties of GP IIb/IIIa blockers

31 March 2020

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Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation

31 March 2020

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Paradoxical inhibition of fibrinogen binding and potentiation of alpha-granule release by specific types of inhibitors of glycoprotein IIb-IIIa

31 March 2020

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31 March 2020

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A reevaluation of integrins as regulators of angiogenesis

31 March 2020

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A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

31 March 2020

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Are changes in integrin affinity and conformation overemphasized?

31 March 2020

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Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit

31 March 2020

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Integrins: bidirectional, allosteric signaling machines

31 March 2020

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Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

31 March 2020

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A controlled trial of natalizumab for relapsing multiple sclerosis

31 March 2020

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Natalizumab for active Crohn's disease

31 March 2020

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Lymphocyte homing and homeostasis

31 March 2020

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Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure

31 March 2020

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Identification of ligand binding sites on integrin alpha4beta1 through chemical cross-linking

31 March 2020

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Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1

31 March 2020

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Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand

31 March 2020

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Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation

31 March 2020

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The immunological synapse: a molecular machine controlling T cell activation

31 March 2020

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Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

31 March 2020

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Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation

31 March 2020

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A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

31 March 2020

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

31 March 2020

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Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

31 March 2020

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Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

31 March 2020

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Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

31 March 2020

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Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

31 March 2020

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Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7

31 March 2020

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Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis

31 March 2020

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31 March 2020

Fibrinogen and fibrin

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COVALENT STRUCTURE OF FIBRINOGEN

31 March 2020

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Predicted and experimental structures of integrins and beta-propellers

31 March 2020

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Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements

31 March 2020

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1174

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7 August 2017

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