(Q35208830)

7 August 2017

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title

MAPK pathways in radiation responses (English)

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7 August 2017

Paul Dent

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7 August 2017

Adly Yacoub

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7 August 2017

Paul B Fisher

series ordinal

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7 August 2017

Michael P Hagan

series ordinal

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7 August 2017

Steven Grant

series ordinal

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7 August 2017

language of work or name

English

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publication date

1 September 2003

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

5885-5896

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Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation.

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis

21 January 2018

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JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor

21 January 2018

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The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation

21 January 2018

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Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity

21 January 2018

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p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony

21 January 2018

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Pro-apoptotic action of PAR-4 involves inhibition of NF-kappaB activity and suppression of BCL-2 expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif

21 January 2018

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Ceramide enables fas to cap and kill.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Isolation of MEK5 and differential expression of alternatively spliced forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

NF-kappa B signaling pathway as a target for human tumor radiosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Role of the p38 and MEK-1/2/p42/44 MAP kinase pathways in the differential activation of human immunodeficiency virus gene expression by ultraviolet and ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Requirement of ATM in UVA-induced signaling and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Components of a new human protein kinase signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

Early growth response-1 gene: potential radiation response gene marker in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Ionizing radiation-inducible apoptosis in the absence of p53 linked to transcription factor EGR-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Regulation of Akt/PKB activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Activation of Raf by ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Determination of cell fate by c-Abl activation in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Raf-1 activates MAP kinase-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Interactions of c-Raf-1 with phosphatidylserine and 14-3-3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.Miko

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206701

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206701

1 reference

7 August 2017

1 reference