(Q35120176)

6 August 2017

1 reference

title

Progress and problems with the use of viral vectors for gene therapy (English)

1 reference

6 August 2017

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728277

30 December 2023

1 reference

30 December 2023

Anja Ehrhardt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728277

30 December 2023

Mark A. Kay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728277

30 December 2023

Clare E. Thomas

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12728277

30 December 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12728277

30 December 2023

publication date

1 May 2003

1 reference

full work available at URL

6 August 2017

https://www.nature.com/articles/nrg1066.pdf

file format

Portable Document Format

1 reference

https://www.nature.com/articles/nrg1066

30 December 2023

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30 December 2023

published in

Nature Reviews Genetics

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

346-358

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Gene therapy: a brief overview of the past, present, and future

6 August 2017

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31 March 2020

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Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

31 March 2020

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A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo

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Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin.

31 March 2020

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Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

31 March 2020

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Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

31 March 2020

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Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

31 March 2020

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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

31 March 2020

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Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration

31 March 2020

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Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

31 March 2020

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A system for the propagation of adenoviral vectors with genetically modified receptor specificities

31 March 2020

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Targeting retroviral vector infection to cells that express heregulin receptors using a TVA-heregulin bridge protein

31 March 2020

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Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands

31 March 2020

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Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo

31 March 2020

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CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.

31 March 2020

1 reference

Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types

31 March 2020

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31 March 2020

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Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism

31 March 2020

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The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.

31 March 2020

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Molecular breeding of viruses

31 March 2020

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Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line

31 March 2020

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

31 March 2020

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

31 March 2020

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Murine leukemia induced by retroviral gene marking

31 March 2020

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Side effects of retroviral gene transfer into hematopoietic stem cells

31 March 2020

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HIV-1 integration in the human genome favors active genes and local hotspots

31 March 2020

1 reference

Site-specific genomic integration produces therapeutic Factor IX levels in mice

31 March 2020

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Stable nonviral genetic correction of inherited human skin disease

31 March 2020

1 reference

A phage integrase directs efficient site-specific integration in human cells

31 March 2020

1 reference

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

31 March 2020

1 reference

Chromosomal effects of adeno-associated virus vector integration

31 March 2020

1 reference

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors

31 March 2020

1 reference

A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction

31 March 2020

1 reference

Epstein-Barr virus vectors for gene expression and transfer

31 March 2020

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Properties of human foamy virus relevant to its development as a vector for gene therapy

31 March 2020

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Gene therapy using SV40-derived vectors: what does the future hold?

31 March 2020

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Evaluation of recombinant alphaviruses as vectors in gene therapy

31 March 2020

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Negative-strand RNA viruses: genetic engineering and applications

31 March 2020

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Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase

31 March 2020

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31 March 2020

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siRNA-mediated gene silencing in vitro and in vivo.

31 March 2020

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31 March 2020

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An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

31 March 2020

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Gene therapy death prompts review of adenovirus vector

31 March 2020

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Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

31 March 2020

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Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import

31 March 2020

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Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery

31 March 2020

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31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

1 reference

Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system

31 March 2020

1 reference

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

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31 March 2020

1 reference

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

31 March 2020

1 reference

Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector

31 March 2020

1 reference

Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Assessment of adenoviral vector safety and toxicity: report of the National Institutes of Health Recombinant DNA Advisory Committee

1 reference

30 December 2023

1 reference

30 December 2023

115

6359

J Nemunaitis

2000

1 reference

30 December 2023

Identifiers

DOI

10.1038/NRG1066

1 reference

Dimensions Publication ID

6 August 2017

1003654890

0 references

1 reference