(Q35062446)

6 August 2017

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title

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer (English)

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6 August 2017

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William G Kaelin

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6 August 2017

William Kim

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6 August 2017

publication date

1 February 2003

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Current Opinion in Genetics & Development

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

55-60

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Molecular basis of the VHL hereditary cancer syndrome

6 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Identification of NEDD8-conjugation site in human cullin-2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Covalent modification of all members of human cullin family proteins by NEDD8

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

How oxygen makes its presence felt

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Characterization and comparative analysis of the EGLN gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Protein tyrosine kinase inhibitors: new treatment modalities?

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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900010-2

7 January 2021

10.1016/S0959-437X(02)00010-2

Identifiers

DOI

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release_kmhek7bpv5funnzrjttmx6df2m

6 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/kmhek7bpv5funnzrjttmx6df2m

24 November 2022

mapped directly with Wikidata item

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